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Report error Found 342 of affinity data for UniProtKB/TrEMBL: P31390
TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  0.300nMAssay Description:Half-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50115644((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50115644((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50449566(CHEMBL414174)
Affinity DataKi:  0.501nMAssay Description:Tested for antagonistic activity on 5-hydroxytryptamine 3 receptor mediated effects of 5-HT in guinea pig isolated ileumMore data for this Ligand-Target Pair
In DepthDetails Article

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50115644((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...)
Affinity DataKi:  0.630nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50079527((3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimet...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50017696((2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiaz...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]pyrilamine from Sprague-Dawley rat H1 receptor assessed as inhibition constant measured after 30 mins by competitive binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35256((S)-mianserin | Lerivon | MIANSERIN | MIANSERIN (+...)
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataKi:  1.20nMAssay Description:Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50062261(CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM81472(CAS_10646 | NSC_10646 | Pyrathiazine)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35256((S)-mianserin | Lerivon | MIANSERIN | MIANSERIN (+...)
Affinity DataKi:  1.78nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35938(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Affinity DataKi:  2nMAssay Description:Ability to displace [3H]-Pyrilamine from histamine H1 receptor in male SpragueDawley rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM84994(CAS_163091 | NSC_163091 | ORG-5222)
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM81464(2-[(4-chlorophenyl)-(2-pyridyl)methoxy]ethyl-dimet...)
Affinity DataKi:  2.30nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM81470(CAS_14677 | Methdilazine | NSC_14677 | US9504692, ...)
Affinity DataKi:  2.30nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50137976(9-(4-Methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f...)
Affinity DataKi:  2.70nMAssay Description:In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50137980(1-Methyl-9-(4-methyl-piperazin-1-yl)-4-thia-10a-az...)
Affinity DataKi:  2.70nMAssay Description:In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50017696((2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiaz...)
Affinity DataKi:  2.90nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  2.90nMAssay Description:In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50111631(6-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-3-methyl-3H-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50017721(1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)pipe...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50241333(4-(benzhydryloxy)-1-methylpiperidine | CHEMBL1492 ...)
Affinity DataKi:  3.20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM22868(11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-b...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50017696((2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiaz...)
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM82548(CAS_897-15-4 | Dothiepin | NSC_3155)
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35256((S)-mianserin | Lerivon | MIANSERIN | MIANSERIN (+...)
Affinity DataKi:  4.07nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataKi:  4.10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50108592((+/-)9-(4-Ethyl-piperazin-1-yl)-7-fluoro-9,10-dihy...)
Affinity DataKi:  4.30nMAssay Description:Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  4.30nMAssay Description:In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM81469(CAS_91-80-5 | Methapyrilene | NSC_4098)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409601(CHEMBL2111783)
Affinity DataKi:  4.60nMAssay Description:Half-maximal inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat frontal cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50330747((-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'...)
Affinity DataKi:  4.68nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50017666(1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopro...)
Affinity DataKi:  4.70nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  5nMAssay Description:Compound was tested for the binding affinity against rat cortical H1 receptor by radioligand [3H]-pyrilamine binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50330752(3-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  5.37nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35938(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM35938(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50292411((E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)py...)
Affinity DataKi:  5.60nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM82479(CAS_132539-06-1 | NSC_4585 | OLANZAPINE | USRE4934...)
Affinity DataKi:  5.60nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50330751(1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dib...)
Affinity DataKi:  5.62nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in Sprague-Dawley rat cortical membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50128888(CHEMBL58973 | [3-(4-Chloro-phenyl)-3-pyridin-2-yl-...)
Affinity DataKi:  6nMAssay Description:Ability to displace [3H]-Pyrilamine from histamine H1 receptor in male SpragueDawley rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50619381(CHEMBL5403228)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]pyrilamine from Sprague-Dawley rat H1 receptor assessed as inhibition constant measured after 30 mins by competitive binding assa...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM22869(6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatric...)
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50063449(8-Chloro-11-piperazin-1-yl-6,11-dihydro-5H-benzo[5...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50073184(8-Chloro-11-(4-methyl-piperazin-1-yl)-6,11-dihydro...)
Affinity DataKi:  6.5nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50111627(6-[2-(4-Benzyl-piperazin-1-yl)-ethyl]-3-methyl-3H-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]- pyrilamine from rat brain membrane Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50128875(CHEMBL292195 | [3-(4-Chloro-phenyl)-3-pyridin-2-yl...)
Affinity DataKi:  7nMAssay Description:Ability to displace [3H]-Pyrilamine from histamine H1 receptor in male SpragueDawley rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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