Compile Data Set for Download or QSAR
Report error Found 163 for UniProtKB: P31939
LigandPNGBDBM50277355(CHEMBL4177183)
Affinity DataIC50: 0.0780nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50277352(CHEMBL4162649)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50243463(CHEMBL4100363)
Affinity DataEC50:  4nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50243463(CHEMBL4100363)
Affinity DataIC50: 5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50243461(CHEMBL4075503)
Affinity DataIC50: 5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243462(CHEMBL4083899)
Affinity DataIC50: 5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243396(CHEMBL1231520)
Affinity DataKi:  6nMAssay Description:Inhibition of human AICARFTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50277353(CHEMBL4170578)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50243415(CHEMBL4063104)
Affinity DataEC50:  7.60nMAssay Description:Inhibition of AICARFT in human MDA-MB-231 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50243486(CHEMBL4081385)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243486(CHEMBL4081385)
Affinity DataEC50:  7.90nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243415(CHEMBL4063104)
Affinity DataEC50:  8nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50277356(CHEMBL4168306)
Affinity DataKi:  8nMAssay Description:Inhibition of recombinant human AICARFTase using AICAR as substrate incubated at 37 degC for 30 mins measured after overnight incubation at 4 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
LigandPNGBDBM66082(SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...)
Affinity DataIC50: 10nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50243462(CHEMBL4083899)
Affinity DataEC50:  10nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243487(CHEMBL4091668)
Affinity DataIC50: 12nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243443(CHEMBL4070790)
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243441(CHEMBL4076500)
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243485(CHEMBL4074469)
Affinity DataIC50: 14nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243415(CHEMBL4063104)
Affinity DataIC50: 16nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50243442(CHEMBL4099409)
Affinity DataEC50:  17nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243434(CHEMBL4079085)
Affinity DataEC50:  18nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243434(CHEMBL4079085)
Affinity DataIC50: 18nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243442(CHEMBL4099409)
Affinity DataIC50: 20nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50369444(CHEMBL608337)
Affinity DataKd:  20nMAssay Description:Binding affinity towards AICAR formyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
LigandPNGBDBM50243441(CHEMBL4076500)
Affinity DataEC50:  21nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243485(CHEMBL4074469)
Affinity DataEC50:  25nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243433(CHEMBL4101204)
Affinity DataIC50: 26nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243487(CHEMBL4091668)
Affinity DataEC50:  27nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243443(CHEMBL4070790)
Affinity DataEC50:  31nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50277351(CHEMBL4174018)
Affinity DataIC50: 43nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50243461(CHEMBL4075503)
Affinity DataEC50:  62nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50243433(CHEMBL4101204)
Affinity DataEC50:  68nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50027656(CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...)
Affinity DataIC50: 70nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  73nMAssay Description:Binding affinity to human ATIC incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50243415(CHEMBL4063104)
Affinity DataEC50:  73nMAssay Description:Inhibition of AICARFT in human MDA-MB-231 cells assessed as increase in ZMP levels using regular folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50277357(CHEMBL4163732)
Affinity DataIC50: 92nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50277354(CHEMBL4166099)
Affinity DataIC50: 107nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50369444(CHEMBL608337)
Affinity DataIC50: 125nMAssay Description:Inhibitory activity against AICAR formyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
LigandPNGBDBM22585(1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadia...)
Affinity DataKi:  130nM ΔG°:  -38.9kJ/molepH: 7.4 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
LigandPNGBDBM22588({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2,2,4-trioxo-1H,3...)
Affinity DataKi:  150nM ΔG°:  -38.6kJ/molepH: 7.4 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
LigandPNGBDBM50158378(5-(5-sulfamoyl-naphthalen-2-ylazo)-naphthalene-1-s...)
Affinity DataKi:  154nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22587(7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)ox...)
Affinity DataKi:  230nM ΔG°:  -37.5kJ/molepH: 7.4 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
LigandPNGBDBM50243415(CHEMBL4063104)
Affinity DataEC50:  356nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using regular folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50243477(CHEMBL4092503)
Affinity DataEC50:  567nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM50158378(5-(5-sulfamoyl-naphthalen-2-ylazo)-naphthalene-1-s...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50243477(CHEMBL4092503)
Affinity DataIC50: 608nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
LigandPNGBDBM92374(RY Analogue, 14)
Affinity DataKi:  685nM ΔG°:  -35.2kJ/moleT: 2°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50005520(2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5...)
Affinity DataIC50: 700nMAssay Description:Hexaglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against MOLT-4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50243414(CHEMBL4084757)
Affinity DataIC50: 723nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
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