Compile Data Set for Download or QSAR
Report error Found 266 of affinity data for UniProtKB/TrEMBL: P45985
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50567687(CHEMBL4865410)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to wild-type human partial length MKK4 (S84 to D399 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human MKK4 using JNK1 (K55M) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50567686(CHEMBL4798975)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to wild-type human partial length MKK4 (S84 to D399 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to MEK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  3.80nMAssay Description:Binding constant for MEK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50567689(CHEMBL4790247)
Affinity DataIC50: 29nMAssay Description:Inhibition of MKK4 (unknown origin) by PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 41nMAssay Description:Inhibition of MEK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 41nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 60nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577661(CHEMBL4879048)
Affinity DataIC50: 61nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558880(US11370770, Compound 6ee)
Affinity DataIC50: 63nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 66nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  70nMAssay Description:Binding constant for MEK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  70nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  70nMAssay Description:Binding constant for MEK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577689(CHEMBL4866649)
Affinity DataIC50: 83nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50567688(CHEMBL4784779)
Affinity DataIC50: 89nMAssay Description:Inhibition of MKK4 (unknown origin) by PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577657(CHEMBL4848865)
Affinity DataIC50: 96nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 100nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50: 100nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558864(US11370770, Compound 6p)
Affinity DataIC50: 110nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558878(US11370770, Compound 6cc)
Affinity DataIC50: 120nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 130nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 132nMAssay Description:Inhibition of MEK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50567686(CHEMBL4798975)
Affinity DataIC50: 146nMAssay Description:Inhibition of MKK4 (unknown origin) by PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558867(US11370770, Compound 6s)
Affinity DataIC50: 150nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  150nMAssay Description:Binding constant for MEK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585045(CHEMBL5093741)
Affinity DataIC50: 173nMAssay Description:Inhibition of MEK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558848(US11370770, Compound 6a)
Affinity DataIC50: 180nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558867(US11370770, Compound 6s)
Affinity DataIC50: 180nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  190nMAssay Description:Binding constant for MEK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50559799(CHEMBL4748767)
Affinity DataIC50: 190nMAssay Description:Inhibition of MEK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  200nMAssay Description:Binding constant for MEK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558866(US11370770, Compound 6r)
Affinity DataIC50: 200nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558865(US11370770, Compound 6q)
Affinity DataIC50: 210nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558867(US11370770, Compound 6s)
Affinity DataIC50: 220nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558858(US11370770, Compound 6j)
Affinity DataIC50: 240nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  250nMAssay Description:Binding constant for MEK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558858(US11370770, Compound 6j)
Affinity DataIC50: 250nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558880(US11370770, Compound 6ee)
Affinity DataIC50: 260nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50607924(CHEMBL5278864)
Affinity DataIC50: 281nMAssay Description:Inhibition of MAP2K4 (unknown origin) at 100 uM preincubated for 1 hr followed by substrate addition and measured after 1 hr by Z-lyte assay relative...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577686(CHEMBL4865159)
Affinity DataIC50: 290nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577647(CHEMBL4849172)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577671(CHEMBL4872723)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  330nMAssay Description:Binding constant for MEK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50: 360nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577673(CHEMBL4858450)
Affinity DataIC50: 380nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577682(CHEMBL4846360)
Affinity DataIC50: 390nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440018(CHEMBL2425628)
Affinity DataKd:  390nMAssay Description:Binding affinity to MEK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Displayed 1 to 50 (of 266 total ) | Next | Last >>
Jump to: