BDBM25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720

SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F

InChI Key InChIKey=YZDJQTHVDDOVHR-UHFFFAOYSA-N

Data  2 KI  27 IC50  442 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 471 hits for monomerid = 25617   

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 160nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 130nMpH: 7.5 T: 2°CAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetTyrosine-protein kinase FRK(Human)
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 1.30E+3nMpH: 7.5 T: 2°CAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 2.30E+3nMpH: 7.5 T: 2°CAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 1.70E+3nMpH: 7.5 T: 2°CAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 1.50E+3nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 1.70E+3nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 1.90E+3nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 2.80E+3nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 3.30E+3nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Plexxikon

LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 3.40E+3nMAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 46nMAssay Description:Inhibition of b-Raf in human A375 cells assessed phosphorylation of ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50: 160nMAssay Description:Inhibition of B-Raf in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for CAMK2B kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for CHEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(G719S) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for CAMKK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 6(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EPHA6 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for CAMK2A kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase BRSK1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for BRSK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(L747-T751del,Sins) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for IKK-alpha kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  5.70E+3nMAssay Description:Binding constant for ABL1(F317L)-phosphorylated kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(G719C) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for CDK4-cyclinD3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(L861Q) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for FLT4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MAP3K4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PRKCH kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  940nMAssay Description:Binding constant for ABL1(F317L)-non phosphorylated kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding constant for GCN2(Kin.Dom.2,S808G) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding constant for ABL1(F317I)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  330nMAssay Description:Binding constant for BRAF kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  38nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TYK2(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(C420R) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  5.80E+3nMAssay Description:Binding constant for KIT(A829P) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(H1047L) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(L747-E749del, A750P) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  2.60E+3nMAssay Description:Binding constant for ABL1(M351T)-phosphorylated kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MET(Y1235D) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ABL1(T315I)-non phosphorylated kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for JAK1(JH1domain-catalytic) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  4.80E+3nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  510nMAssay Description:Binding constant for ABL1(H396P)-non phosphorylated kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyotonin-protein kinase(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for DMPK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(M1043I) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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