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TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50611804(CHEMBL5278261)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50124354(CHEMBL3623439)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299583((S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methy...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50611805(CHEMBL5275331)
Affinity DataIC50: 1nMAssay Description:Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50124355(CHEMBL3623442)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo-HCl | US9221808, 1bo-Mes | US922180...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of LIMK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human LIMK1 using cofilin as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human LIMK1 using cofilin as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622459(US20230312576, Compound 136)
Affinity DataKi:  2.75nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human LIMK1 using cofilin 1 as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50124400(CHEMBL3623438)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50124352(CHEMBL3623441)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 3nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50124400(CHEMBL3623438)
Affinity DataIC50: 3nMAssay Description:Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622485(US20230312576, Compound 198)
Affinity DataKi:  3.08nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299584((S)-N-(3-bromo-4-fluorophenyl)-N'-cyano-2-methyl-4...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622431(US20230312576, Compound 93)
Affinity DataKi:  3.71nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622431(US20230312576, Compound 93)
Affinity DataKi:  4nMAssay Description:Inhibition of LIMK1 (unknown origin) assessed as inhibition constant by LanthScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50124399(CHEMBL3623437)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50327391(N1-(4-(2-chlorophenyl)-6-(2-(isopropylamino)thiazo...)
Affinity DataIC50: 4.01nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622495(US20230312576, Compound 222)
Affinity DataKi:  4.59nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622493(US20230312576, Compound 216)
Affinity DataKi:  4.88nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622494(US20230312576, Compound 219)
Affinity DataKi:  4.93nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622460(US20230312576, Compound 137)
Affinity DataKi:  4.97nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622433(US20230312576, Compound 110)
Affinity DataKi:  5nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50: 5nMAssay Description:Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50591311(CHEMBL3182065)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-fused human LIMK1 (321 to 647 residues) expressed in Sf9 cells incubated for 30 mins by Topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50124397(CHEMBL3623435)
Affinity DataIC50: 5nMAssay Description:Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50124397(CHEMBL3623435)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622438(US20230312576, Compound 115)
Affinity DataKi:  5.37nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622434(US20230312576, Compound 111)
Affinity DataKi:  5.78nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  6nMAssay Description:Binding affinity to truncated human N-terminal GST-tagged LIMK1 (285 to 638 residues) expressed in baculovirus expression system using cofilin2 as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622444(US20230312576, Compound 121)
Affinity DataKi:  6.10nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622447(US20230312576, Compound 124)
Affinity DataKi:  6.49nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50299585((S)-N-(3-bromo-4-fluorophenyl)-2-methyl-4-(5-methy...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622427(US20230312576, Compound 89)
Affinity DataKi:  6.60nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50591091(CHEMBL5169387)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) expressed in baculovirus infected insect cells using CFL1 as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622427(US20230312576, Compound 89)
Affinity DataKi:  7nMAssay Description:Inhibition of LIMK1 (unknown origin) assessed as inhibition constant by LanthScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50: 7nMAssay Description:Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50: 7nMAssay Description:Inhibition of human glutathione S-transferase-tagged LIMK1 (321 to 647 residues) expressed in baculovirus-infected Sf9 cells incubated for 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50591090(CHEMBL2141887)
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-fused human LIMK1 (321 to 647 residues) expressed in Sf9 cells incubated for 30 mins by Topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622435(US20230312576, Compound 112)
Affinity DataKi:  7nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622445(US20230312576, Compound 122)
Affinity DataKi:  7.11nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Universita Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM622436(US20230312576, Compound 113)
Affinity DataKi:  7.13nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

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