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TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50541929(CHEMBL1738785)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human CHIT1 using 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotriose as substrate assessed as substrate hydrolysis by measuring ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50214361(CHEMBL415389)
Affinity DataIC50: 7.53nMAssay Description:Compound was evaluated for inhibitory activity against Trichoderma ChitinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM10854(4-[(1S,4R,10S,13S,16S,18R)-10-{3-[(acetamidomethan...)
Affinity DataIC50: 13nMpH: 5.2 T: 2°CAssay Description:The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2006
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50554342(CHEMBL4776610)
Affinity DataIC50: 14nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50554344(CHEMBL4756869)
Affinity DataIC50: 16nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50214358(CHEMBL318258)
Affinity DataIC50: 16.1nMAssay Description:Compound was evaluated for inhibitory activity against Trichoderma ChitinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50554340(CHEMBL4788866)
Affinity DataKi:  17nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50554343(CHEMBL4794014)
Affinity DataIC50: 18nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504025(CHEMBL4464754)
Affinity DataIC50: 21nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50554347(CHEMBL4755139)
Affinity DataIC50: 22nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50554345(CHEMBL4789376)
Affinity DataIC50: 22nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50554340(CHEMBL4788866)
Affinity DataIC50: 23nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50554346(CHEMBL4764430)
Affinity DataIC50: 23nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504017(CHEMBL4541831)
Affinity DataIC50: 27nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50554348(CHEMBL4749391)
Affinity DataIC50: 32nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50243685(CHEMBL4084573)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged chitotriosidase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N',N"...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50214357(CHEMBL319102)
Affinity DataIC50: 41nMAssay Description:Compound was evaluated for inhibitory activity against Trichoderma ChitinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504019(CHEMBL4580568)
Affinity DataIC50: 41nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504019(CHEMBL4580568)
Affinity DataIC50: 41nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50214360(CHEMBL327266)
Affinity DataIC50: 41.1nMAssay Description:Compound was evaluated for inhibitory activity against Trichoderma ChitinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504037(CHEMBL4470253)
Affinity DataIC50: 44nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504028(CHEMBL4520755)
Affinity DataIC50: 44nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504016(CHEMBL4537828)
Affinity DataIC50: 47nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504024(CHEMBL4461925)
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504024(CHEMBL4461925)
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50541930(CHEMBL4637417)
Affinity DataIC50: 49nMAssay Description:Inhibition of full length recombinant C-terminal His-taged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50641171(CHEMBL5570010)
Affinity DataIC50: 49nMAssay Description:Inhibition of human C-terminal His tagged CHIT1 expressed in CHO-K1 cells using 4-methylumbelliferyl beta-D-N,N',N''-triacetylchitotrioside as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50514508(CHEMBL4549449)
Affinity DataKi:  49nMAssay Description:Inhibition of human CHIT1 catalytic domain overexpressed in Pichia pastoris using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504034(CHEMBL4588384)
Affinity DataIC50: 59nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50541931(CHEMBL4634943)
Affinity DataIC50: 79nMAssay Description:Inhibition of full length recombinant C-terminal His-taged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50214359(CHEMBL103401)
Affinity DataIC50: 80nMAssay Description:Compound was evaluated for inhibitory activity against Trichoderma ChitinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504039(CHEMBL4442663)
Affinity DataIC50: 82nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504031(CHEMBL4521547)
Affinity DataIC50: 84nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50504014(CHEMBL4547227)
Affinity DataIC50: 87nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50541933(CHEMBL4646309)
Affinity DataIC50: 90nMAssay Description:Inhibition of full length recombinant C-terminal His-taged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM349956(5-(4-((2S,4S)-2-(4-chlorobenzyl)-4-methoxypyrrolid...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM349957((3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM349925((R)-5-(2-(4-chlorobenzyl)-[1,4′-bipiperidin]...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM349924(5-(4-((2R,5S)-5-(4-chlorobenzyl)-2-(2-methoxypropa...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM349926(ethyl (6R)-1′-(5-amino-4H-1,2,4-triazol-3-yl...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM601671(US11638707, Example 76.)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC:276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM601670(US11638707, Example 75.)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC:276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM601673(US11638707, Example 78.)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC:276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM349960((3R,5S)-1-(1-(5-amino-1H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM349961(3-(4-((2S,4R)-2-(4-chlorobenzyl)-4-methoxypyrrolid...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM349934((R)-5-(4-(2-(4-chlorobenzyl)pyrrolidin-1-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM601601(US11638707, Example 6.)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC:276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM601603(US11638707, Example 8.)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC:276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM601602(US11638707, Example 7.)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC:276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetChitotriosidase-1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM601604(US11638707, Example 9.)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC:276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

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