Compile Data Set for Download or QSAR
Report error Found 395 for UniProtKB: Q13233
LigandPNGBDBM636782(US20230382863, Compound I-2)
Affinity DataKd:  0.144nMAssay Description:Table 11: The experiments were performed on Biacore S200 (Cytiva). Biotinylated, unphosphorylated MEK1 was diluted to 0.1 uM by SPR buffer C (20 mM T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636825(US20230382863, Compound I-54)
Affinity DataKd:  0.350nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636825(US20230382863, Compound I-54)
Affinity DataKd:  0.350nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636825(US20230382863, Compound I-54)
Affinity DataKd:  0.350nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636782(US20230382863, Compound I-2)
Affinity DataKd:  0.370nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636782(US20230382863, Compound I-2)
Affinity DataKd:  0.370nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636782(US20230382863, Compound I-2)
Affinity DataKd:  0.370nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636816(US20230382863, Compound I-45)
Affinity DataKd:  0.380nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636816(US20230382863, Compound I-45)
Affinity DataKd:  0.380nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636816(US20230382863, Compound I-45)
Affinity DataKd:  0.380nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636781(US20230382863, Compound I-1)
Affinity DataKd:  0.420nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636781(US20230382863, Compound I-1)
Affinity DataKd:  0.420nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636781(US20230382863, Compound I-1)
Affinity DataKd:  0.420nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636826(US20230382863, Compound I-40)
Affinity DataKd:  0.470nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636826(US20230382863, Compound I-40)
Affinity DataKd:  0.470nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636826(US20230382863, Compound I-40)
Affinity DataKd:  0.470nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636824(US20230382863, Compound I-41)
Affinity DataKd:  0.480nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636824(US20230382863, Compound I-41)
Affinity DataKd:  0.480nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636824(US20230382863, Compound I-41)
Affinity DataKd:  0.480nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636815(US20230382863, Compound I-43)
Affinity DataKd:  0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636815(US20230382863, Compound I-43)
Affinity DataKd:  0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636815(US20230382863, Compound I-43)
Affinity DataKd:  0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636818(US20230382863, Compound I-55)
Affinity DataKd:  0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636818(US20230382863, Compound I-55)
Affinity DataKd:  0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636818(US20230382863, Compound I-55)
Affinity DataKd:  0.510nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636814(US20230382863, Compound I-42)
Affinity DataKd:  0.570nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636814(US20230382863, Compound I-42)
Affinity DataKd:  0.570nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636814(US20230382863, Compound I-42)
Affinity DataKd:  0.570nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636818(US20230382863, Compound I-55)
Affinity DataKd:  1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM350231(US20230270730, Compound A-13 | US11964950, Compoun...)
Affinity DataIC50: 1nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

LigandPNGBDBM636815(US20230382863, Compound I-43)
Affinity DataKd:  1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614413(US20230270730, Compound N-2 | US11964950, Compound...)
Affinity DataIC50: 1nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

LigandPNGBDBM636825(US20230382863, Compound I-54)
Affinity DataKd:  1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614412(US20230270730, Compound N-1 | US11964950, Compound...)
Affinity DataIC50: 1nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

LigandPNGBDBM636824(US20230382863, Compound I-41)
Affinity DataKd:  1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636782(US20230382863, Compound I-2)
Affinity DataKd:  1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636781(US20230382863, Compound I-1)
Affinity DataKd:  1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636826(US20230382863, Compound I-40)
Affinity DataKd:  1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM636814(US20230382863, Compound I-42)
Affinity DataKd:  1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614413(US20230270730, Compound N-2 | US11964950, Compound...)
Affinity DataIC50: 1nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 6 below were evaluated by the fluorescent polarization method as described below. The t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614412(US20230270730, Compound N-1 | US11964950, Compound...)
Affinity DataIC50: 1nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 6 below were evaluated by the fluorescent polarization method as described below. The t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
US Patent

LigandPNGBDBM636816(US20230382863, Compound I-45)
Affinity DataKd:  1nMAssay Description:Table 8: Exemplary MEK inhibitor compounds (0, 0.01, 0.1, or 1 μM) were added to a 384-AlphaPlate (PerkinElmer, 6008350) by a digital liquid dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614303(US20230270730, Compound B-9 | US11964950, Compound...)
Affinity DataIC50: 2nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614296(US20230270730, Compound B-1 | US11964950, Compound...)
Affinity DataIC50: 2nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614293(US20230270730, Compound A-45 | US11964950, Compoun...)
Affinity DataIC50: 2nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM668752(3,4-Difluoro-2-[(4-fluoro-1-benzothiophen-5-yl)ami...)
Affinity DataIC50: 2nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614415(US20230270730, Compound P-1 | US11964950, Compound...)
Affinity DataIC50: 2nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614296(US20230270730, Compound B-1 | US11964950, Compound...)
Affinity DataIC50: 2nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 6 below were evaluated by the fluorescent polarization method as described below. The t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM350232(US20230270730, Compound A-14 | US11964950, Compoun...)
Affinity DataIC50: 2nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM614415(US20230270730, Compound P-1 | US11964950, Compound...)
Affinity DataIC50: 2nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 6 below were evaluated by the fluorescent polarization method as described below. The t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
US Patent

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