Compile Data Set for Download or QSAR
Report error Found 585 for UniProtKB: Q5W154
LigandChemical structure of BindingDB Monomer ID 50408479BDBM50408479(CHEMBL5180503)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PDE7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50068287BDBM50068287(CHEMBL3403346)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of PDE7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 116309BDBM116309(US8637528, OM69)
Affinity DataIC50: 4.80nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50649877BDBM50649877(CHEMBL5625053)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of full length PDE7 (unknown origin) using FAM-cAMP as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50649876BDBM50649876(CHEMBL5630856)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of full length PDE7 (unknown origin) using FAM-cAMP as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50381299BDBM50381299(CHEMBL2019112)
Affinity DataIC50: 8nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 116310BDBM116310(US8637528, OM056)
Affinity DataIC50: 9.27nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724716BDBM724716(N-((1r,4r)-4-(4-acet- ylpiperazin-1-yl)- cyclohexy...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607107BDBM607107(US11685745, Example 64)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607106BDBM607106(US11685745, Example 51)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607105BDBM607105(US11685745, Example 43)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607104BDBM607104(US11685745, Example 37)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607111BDBM607111(US11685745, Example 189)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724689BDBM724689(1-(4,4-difluorocyclo- hexyl)-N-((1r,4r)-4- (4-isop...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724721BDBM724721(N-((1r,4r)-4-(3- (difluoromethoxy)- azetidin-1-yl)...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607110BDBM607110(US11685745, Example 176)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607109BDBM607109(US11685745, Example 123)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724688BDBM724688(N-((1r,4r)-4-(4-acet- ylpiperazin-1-yl)- cyclohexy...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724720BDBM724720(1-(4,4-difluorocyclo- hexyl)-N-((1r,4r)-4- (3-(dif...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607108BDBM607108(US11685745, Example 79)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724711BDBM724711(3-methyl-N-((1r,4r)- 4-morpholinocyclo- hexyl)-1-n...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724710BDBM724710(N-((1r,4r)-4-(4-iso- propylpiperazin-1- yl)cyclohe...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724709BDBM724709(N-((1r,4r)-4-(3,3- difluoroazetidin-1- yl)cyclohex...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724715BDBM724715(N-((1r,4r)-4-(3- cyanoazetidin-1-yl)- cyclohexyl)-...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724703BDBM724703(N-((1r,4r)-4-(4-cyclo- propylpiperazin-1-yl)- cycl...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724675BDBM724675(N-((1r,4r)-4-(4-acetyl- piperazin-1-yl)cyclo- hexy...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724706BDBM724706(N-((1r,4r)-4-(3,3- difluoropyrrolidin-1- yl)cycloh...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724705BDBM724705(1-(4,4-difluorocyclo- hexyl)-N-((1r,4r)-4- (3,3-di...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50649881BDBM50649881(CHEMBL5625119)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length PDE7 (unknown origin) using FAM-cAMP as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 607115BDBM607115(US11685745, Example 334)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607194BDBM607194(US11685745, Example 111)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 607114BDBM607114(US11685745, Example 332)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607249BDBM607249(US11685745, Example 184)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 607112BDBM607112(US11685745, Example 225)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607119BDBM607119(US11685745, Example 427)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607118BDBM607118(US11685745, Example 378)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607116BDBM607116(US11685745, Example 336)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607123BDBM607123(US11685745, Example 557)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607122BDBM607122(US11685745, Example 545)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607121BDBM607121(US11685745, Example 492)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 724696BDBM724696(N-((1r,4r)-4-(3,3- difluoroazetidin-1- yl)cyclohex...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 607124BDBM607124(US11685745, Example 581 | US11685745, Example 576)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50397053BDBM50397053(CHEMBL2171422)
Affinity DataIC50: 11nMAssay Description:Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50649870BDBM50649870(CHEMBL5630984)
Affinity DataIC50: 14nMAssay Description:Inhibition of PDE7B (unknown origin) by 3H-cAMP scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50151605BDBM50151605(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant PDE7 (unknown origin) expressed in Escherichia coli BL21 (DE3) using [3H]cAMP as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50151593BDBM50151593(8''-chloro-6''-phenylspiro[cyclohexane-1,4''-(1'',...)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant PDE7 (unknown origin) expressed in Escherichia coli BL21 (DE3) using [3H]cAMP as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50381291BDBM50381291(CHEMBL2019104)
Affinity DataIC50: 17nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50408478BDBM50408478(CHEMBL5196667)
Affinity DataIC50: 17nMAssay Description:Inhibition of PDE7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 607106BDBM607106(US11685745, Example 51)
Affinity DataIC50: 19nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 50397052BDBM50397052(CHEMBL2171423)
Affinity DataIC50: 19nMAssay Description:Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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