BDBM18627 (10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-5-one::Mifeprex::Mifepristone::RU-486::RU486 (tetramethyl-rhodamine conjugated)
SMILES [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C
InChI Key InChIKey=VKHAHZOOUSRJNA-GCNJZUOMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 192 hits for monomerid = 18627
Affinity DataKi: 0.0900nMAssay Description:Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.100nMAssay Description:Inhibition of human glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Displacement of 10 nM [3H]dexamethasone from human Glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Displacement of [3H]DEX from human glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.251nMAssay Description:Inhibition of 4 nM progesterone-stimulated transactivation of MMTV-Luc reporter in CV-1 cells expressing PR-BMore data for this Ligand-Target Pair
Affinity DataKi: 0.299nMAssay Description:Displacement of [3H]-dexamethasone from human glucocorticoid receptor expressed in HEK293 cells by scintillation counting based radioligand competiti...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
Affinity DataKi: 0.440nMAssay Description:Inhibition of glucocorticoid receptor dependent alkaline phosphatase activityMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
Affinity DataKi: 0.640nMAssay Description:Inhibition of human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.650nMAssay Description:Inhibition of human androgen receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.680nMAssay Description:Binding affinity was determined for human glucocorticoid receptor(hGR).More data for this Ligand-Target Pair
Affinity DataKi: 0.820nMAssay Description:Binding affinity to glucocorticoid receptor in SW1353 cells by whole-cell binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.840nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.998nMAssay Description:Displacement of [3H]-progesterone from human progesterone receptor expressed in HEK293 cells by scintillation counting based radioligand competition ...More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity towards progesterone receptor was measuredMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of radiolabeled Dexamethasone from human GRMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity against Baculovirus-Expressed hPR-AMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Antagonist activity at human glucocorticoid receptor in SW1353 cells assessed as inhibition of dexamethasone-induced luciferase expression by MMTV5 r...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Antagonist activity at GR in SW1353/MMTV5 cells assessed as inhibition of dexamethasone-induced luciferase expressionMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Antagonist activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of dexamethasone-induced tyrosine amino transferase activi...More data for this Ligand-Target Pair
Affinity DataKi: 4.60nMAssay Description:Displacement of [3H]DHT from human Androgen receptorMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Inhibition of human GR expressed in hGRAF cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Displacement of [3H]-methyltrienolone from human androgen receptor expressed in HEK293 cells by scintillation counting based radioligand competition ...More data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Displacement of [3H]-dexamethasone from cytosolic fraction of human recombinant glucocorticoid receptor by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Displacement of [3H]DHT from human androgen receptor after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of fluorescent ligand from binding domain of progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Binding affinity determined against human Androgen receptorMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Displacement of radioligand from human Progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Displacement of [3H]-progesterone from cytosolic fraction of human recombinant progesterone-B receptor by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Binding affinity for human androgen receptor in transiently-transfected COS-1 cells.More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Inhibition of glucocorticoid receptor mediated tyrosine amino transferase activityMore data for this Ligand-Target Pair
Affinity DataKi: 169nMAssay Description:Inhibition of human GR transcriptional activation by HepTAT cellsMore data for this Ligand-Target Pair
Affinity DataKi: 640nMAssay Description:Inhibition of human Mineralocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 851nMAssay Description:Displacement of [3H]-aldosterone from human mineralocorticoid receptor expressed in HEK293 cells by scintillation counting based radioligand competit...More data for this Ligand-Target Pair
Affinity DataKi: >1.25E+3nMAssay Description:Inhibition of human Thyroid hormone receptor alphaMore data for this Ligand-Target Pair
Affinity DataKi: >2.25E+3nMAssay Description:Inhibition of human Thyroid hormone receptor betaMore data for this Ligand-Target Pair
Affinity DataKi: 4.70E+3nMAssay Description:Mechanism based inhibition of human cytochrome P450 3A4 measured by testosterone 6-beta hydroxylationMore data for this Ligand-Target Pair
Affinity DataKi: 4.70E+3nMAssay Description:Inactivation of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]aldosterone from human mineralocorticoid receptor after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nM EC50: 4.80nMpH: 8.0 T: 4°CAssay Description:For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMpH: 8.0 T: 4°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMpH: 8.0 T: 4°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Affinity DataIC50: 8.80nMpH: 8.0 T: 4°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMpH: 8.0 T: 4°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair