Affinity DataKi: 0.600nMAssay Description:Inhibition of APN in porcine kidney using Ala-p-NA as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of APN in porcine kidney using Ala-p-NA as substrateMore data for this Ligand-Target Pair
TargetSphingosine kinase 1(Homo sapiens (Human))
Penn State Hershey Cancer Institute
Curated by ChEMBL
Penn State Hershey Cancer Institute
Curated by ChEMBL
Affinity DataKi: 4.30nMAssay Description:Competitive inhibition of C-terminal His6-tagged human recombinant SphK1 expressed in baculovirus-infected Sf9 cells using sphingosine as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of APN in human placenta using AlabetaNA as substrateMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue preincubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of APA (unknown origin) using GlubetaNA as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Competitive inhibition of aminopeptidase-M (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Competitive inhibition of aminopeptidase-M (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of aminopeptidase-M (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Competitive inhibition of LAP in porcine kidney microsomesMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 30 mins and TCEP absent during reaction by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Inhibition of hog kidney APN using [3H]Tyr1-Leu5-enkephalin as substrate preincubated for 15 mins followed by substrate addition measured after 15 mi...More data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Inhibition of hog kidney APN using [3H]Tyr1-Leu5-enkephalin as substrate preincubated for 15 mins followed by substrate addition measured after 15 mi...More data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Inhibition of APN in porcine kidney using L-leucine p-nitroanilide as substrate preincubated for 60 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Inhibition of hog kidney APN using [3H]Tyr1-Leu5-enkephalin as substrate preincubated for 15 mins followed by substrate addition measured after 15 mi...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 39nMAssay Description:Inhibition of Clostridium botulinum truncated-BoNT/A light chain 424 residue preincubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 41nMAssay Description:Inhibition of protease activity of Clostridium botulinum BoNT/A using N(K)-acetyl)-SNKTRIDEANQRATKML-carboxamide as substrateMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 46nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 60 mins and TCEP absent during reaction by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Inhibition of LAP (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 67nMAssay Description:Inhibition of APA (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Inhibition of aminopeptidase-M (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Inhibition of APN in porcine kidney using Ala-betaNA as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by f...More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Inhibition of APN (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Inhibition of hog kidney APN using [3H]Tyr1-Leu5-enkephalin as substrate preincubated for 15 mins followed by substrate addition measured after 15 mi...More data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Inhibition of APA (unknown origin) using GluNA as substrateMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 157nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 30 mins and TCEP present during reaction by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 162nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 60 mins and TCEP present during reaction by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Competitive inhibition of aminopeptidase-M (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Inhibition of hog kidney APN using [3H]Tyr1-Leu5-enkephalin as substrate preincubated for 15 mins followed by substrate addition measured after 15 mi...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 330nMAssay Description:Inhibition of protease activity of Clostridium botulinum BoNT/A using N(K)-acetyl)-SNKTRIDEANQRATKML-carboxamide as substrateMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 468nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue preincubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 700nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain using SNAP-25 as substrate by LC/MS analysisMore data for this Ligand-Target Pair
Affinity DataKi: 870nMAssay Description:Inhibition of aminopeptidase-M (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Inhibition of APB in rat testis using ArgbetaNA as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Inhibition of pig APNMore data for this Ligand-Target Pair
Affinity DataKi: 1.01E+3nMAssay Description:Inhibition of human APNMore data for this Ligand-Target Pair
TargetSphingosine kinase 1(Homo sapiens (Human))
Penn State Hershey Cancer Institute
Curated by ChEMBL
Penn State Hershey Cancer Institute
Curated by ChEMBL
Affinity DataKi: 1.06E+3nMAssay Description:Competitive inhibition of recombinant sphingosine kinase 1 using D-erythro-sphingosine as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type E(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 1.29E+3nMAssay Description:Inhibition of protease activity of Clostridium botulinum BoNT/E light chain using SNAP-25 as substrate after 15 mins by Dixon plot analysisMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type E(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 1.29E+3nMAssay Description:Inhibition of protease activity of Clostridium botulinum BoNT/E using SNAP-25 as substrate after 15 mins by HPLC based assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30E+3nMAssay Description:Inhibition of LAP (unknown origin)More data for this Ligand-Target Pair
TargetSphingosine kinase 1(Homo sapiens (Human))
Penn State Hershey Cancer Institute
Curated by ChEMBL
Penn State Hershey Cancer Institute
Curated by ChEMBL
Affinity DataKi: 1.33E+3nMAssay Description:Competitive inhibition of recombinant sphingosine kinase 1 using D-erythro-sphingosine as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.63E+3nMAssay Description:Inhibition of pig APNMore data for this Ligand-Target Pair
Affinity DataKi: 1.95E+3nMAssay Description:Inhibition of pig APNMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory
Curated by ChEMBL
Brookhaven National Laboratory
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of protease activity of Clostridium botulinum BoNT/A using N(K)-acetyl)-SNKTRIDEANQRATKML-carboxamide as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 2.01E+3nMAssay Description:Inhibition of human APNMore data for this Ligand-Target Pair
Affinity DataKi: 2.70E+3nMAssay Description:Inhibition of hog kidney APN using [3H]Tyr1-Leu5-enkephalin as substrate preincubated for 15 mins followed by substrate addition measured after 15 mi...More data for this Ligand-Target Pair
Affinity DataKi: 2.90E+3nMAssay Description:Inhibition of pig APNMore data for this Ligand-Target Pair
TargetSphingosine kinase 1(Homo sapiens (Human))
Penn State Hershey Cancer Institute
Curated by ChEMBL
Penn State Hershey Cancer Institute
Curated by ChEMBL
Affinity DataKi: 3.00E+3nMAssay Description:Competitive inhibition of SphK1 (unknown origin)More data for this Ligand-Target Pair
TargetSphingosine kinase 1(Homo sapiens (Human))
Penn State Hershey Cancer Institute
Curated by ChEMBL
Penn State Hershey Cancer Institute
Curated by ChEMBL
Affinity DataKi: 3.10E+3nMAssay Description:Competitive inhibition of human recombinant SphK1 using sphingosine and ATP as substrate by ADP-Quest kinase assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.80E+3nMAssay Description:Displacement of [3H]-epibatidine from Lymnaea stagnalis Acetylcholine-binding protein measured after 1 hr by liquid scintillation counterMore data for this Ligand-Target Pair