BindingDB PrimarySearch

Found 15 of ic50 for monomerid = 28700

Peroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: >1.00E+4nMAssay Description:Displacement of tritium labeled ligand from human PPARalpha by SPA assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: >1.00E+4nMAssay Description:Displacement of tritium labeled ligand from human PPARgamma by SPA assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: >1.00E+4nMAssay Description:Mean inhibitory concentration against human peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: >1.00E+4nMAssay Description:Mean inhibitory concentration against human peroxisome proliferator-activated receptor gammaMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: >1.00E+4nMAssay Description:Displacement of [3H]2-methyl-2-(4-{3-propyl-(5-pyridin-2yl-thiophene-2-sulfonyl)-amino]-pro-pyl}-phenoxy)-propionic acid from human PPARgammaMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: >1.00E+4nMAssay Description:Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from hPPARalphaMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: >1.00E+4nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: 2.40E+4nMAssay Description:Inhibitory activity against human Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: >2.50E+4nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: 3.50E+4nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor alpha bindingMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: >5.00E+4nMAssay Description:Inhibition of human Peroxisome proliferator activated receptor gamma bindingMore data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: 6.80E+4nMAssay Description:Binding affinity towards human peroxidase proliferator activated receptor alpha (hPPARalpha)More data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: 1.06E+5nMAssay Description:Displacement of radio labeled 2(S)-(2-benzoyl-phenylamino)-3-{4-[1,1-ditritio-2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid from G...More data for this Ligand-Target Pair

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3D Structure (crystal)

Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: 7.44E+5nMAssay Description:Displacement of radio labeled 2(S)-(2-benzoyl-phenylamino)-3-{4-[1,1-ditritio-2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid from G...More data for this Ligand-Target Pair

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3D Structure (crystal)

Prostaglandin G/H synthase 1(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL

BDBM28700(2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropionic a...)

IC50: 9.50E+5nMAssay Description:Inhibition of human recombinant COX1 expressed in Sf9 cell microsomes assessed as reduction in conversion of arachidonic acid to PGE2 incubated for 5...More data for this Ligand-Target Pair

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Filter my 15 hits

Targets 3▿
- Peroxisome proliferator-activated receptor alpha 8
- Peroxisome proliferator-activated receptor gamma 6
- Prostaglandin G/H synthase 1 1
Publications 9▿
- J Med Chem 48: 2248-50 (2005) 2
- Bioorg Med Chem Lett 19: 2468-73 (2009) 2
- Bioorg Med Chem Lett 16: 6328-33 (2006) 2
- Bioorg Med Chem Lett 15: 51-5 (2004) 2
- Bioorg Med Chem Lett 16: 6293-7 (2006) 2
- J Med Chem 48: 2262-5 (2005) 2
- J Med Chem 46: 5121-4 (2003) 1
- J Med Chem 59: 4121-51 (2016) 1
- J Med Chem 44: 2061-4 (2001) 1
Institutions 5▿
- Eli Lilly 8
- Merck Research Laboratories 2
- F. Hoffmann-La Roche 2
- Bristol-Myers Squibb Pharmaceutical Research Institute 2
- Tu Dortmund University 1
Affinity: 1.0E+4 to 9.5E+5 nM▿
- IC50 15
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1