Report error Found 91 Enz. Inhib. hit(s) with all data for entry = 50016242
TargetHistone-lysine N-methyltransferase EZH2(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataKi: <0.100nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Binding affinity towards human CB2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Binding affinity towards human CB2 receptorMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibition of recombinant human MIF tautomerase activity using 4-hydroxyphenyl pyruvic acid (HPP) as substrate pre-incubated for 30 mins and followed...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Antagonist activity at sigma1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Antagonist activity at sigma1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataKi: 37nMAssay Description:Inhibition of recombinant human MIF tautomerase activity using 4-hydroxyphenyl pyruvic acid (HPP) as substrate pre-incubated for 30 mins and followed...More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Binding affinity towards human CB2 receptorMore data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataKi: 230nMAssay Description:Inhibition of recombinant human MIF tautomerase activity using 4-hydroxyphenyl pyruvic acid (HPP) as substrate pre-incubated for 30 mins and followed...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.0560nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.178nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in Abeta42 levelsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.225nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in Abeta42 levelsMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.370nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human sEH using CMNPC as substrate incubated for 10 mins and measured by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin)More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at TRPV1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as decrease in free Abeta42 levelsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as decrease in total Abeta42 levelsMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of Cav3.3 subunit 1alpha-l(unknown origin) stably transfected in HEK293 cells measured by FLIPR assayMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 9.20nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as decrease in free Abeta42 levelsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of p110alpha (unknown origin)More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as decrease in total Abeta42 levelsMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Antagonist activity at TRPV1 (unknown origin)More data for this Ligand-Target Pair
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of PDE6 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of human GSK3AMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of Plasmodium falciparum 3D7 plasmepsin IIMore data for this Ligand-Target Pair
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of Cav3.3 subunit 1alpha-l(unknown origin) stably transfected in HEK293 cells measured by FLIPR assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibition of p110alpha (unknown origin)More data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Antagonist activity at human CRF1 receptorMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Antagonist activity at human CRF1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 81nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin)More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 127nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin)More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 136nMAssay Description:Inhibition of recombinant human sEH using CMNPC as substrate incubated for 10 mins and measured by fluorescence assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human GSK3BMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of human GSK3AMore data for this Ligand-Target Pair
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Indian Institute of Technology (B.H.U.)
Curated by ChEMBL
Affinity DataIC50: 339nMAssay Description:Inhibition of PDE6 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assayMore data for this Ligand-Target Pair