BDBM50015448 CHEMBL3265032
SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
InChI Key InChIKey=XSMSNFMDVXXHGJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 50015448
Affinity DataIC50: 7.70nMAssay Description:Inhibition of full length Syk (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 11nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 26nMAssay Description:Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 367nMAssay Description:Inhibition of Syk in goat antihuman IgE-induced CD63 expression in human whole blood by FACS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 453nMAssay Description:Inhibition of Jak2 in erythropoietin-stimulated human TF1 cells assessed as assessed as phospho-Stat5 after 1 hr incubationMore data for this Ligand-Target Pair
Affinity DataEC50: 445nMAssay Description:Inhibition of cKit in stem cell factor-stimulated bone marrow derived mouse mast cells assessed as phosphorylation after 1 hr incubationMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataEC50: 327nMAssay Description:Inhibition of Flt3 in human MV411 cells assessed as assessed as proliferation after 72 hrs incubation by spectrophotometryMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of Ret in human SK-M-MC cells assessed as assessed as phosphorylation after 1 hr incubationMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of KDR in VEGF-stimulated HUVEC assessed as phosphorylation after 1 hr incubationMore data for this Ligand-Target Pair
Affinity DataEC50: 125nMAssay Description:Inhibition of Syk in alphaIgM-stimulated human B cells assessed as CD86 expression after 1 hr incubation by flow cytometryMore data for this Ligand-Target Pair
Affinity DataEC50: 41nMAssay Description:Inhibition of Syk in alphaIgM-stimulated human B cells assessed as cell proliferation after 1 hr incubation by flow cytometryMore data for this Ligand-Target Pair
Affinity DataIC50: 147nMAssay Description:Inhibition of Syk in immune complex-stimulated human monocyte assessed as TNFalpha production after 1 hr incubationMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 377nMAssay Description:Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes assessed as phospho-SLP76 level preincubated for 30 mins followed by anti-CD32 stimul...More data for this Ligand-Target Pair
Affinity DataIC50: 878nMAssay Description:Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of SYK (unknown origin) using XL665-labeled peptide as substrate in presence of ATP measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...More data for this Ligand-Target Pair
Affinity DataEC50: 178nMAssay Description:Inhibition of SYK in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-induced basophil activation by measuring decrease in CD63 surfac...More data for this Ligand-Target Pair
Affinity DataIC50: 82nMAssay Description:Inhibition of SYK (unknown origin) using poly(Glu, Tyr) 4:1 as substrate incubated in presence of [gamma33P]ATP by image analyserMore data for this Ligand-Target Pair
Affinity DataIC50: 801nMAssay Description:Inhibition of BTK (unknown origin) using poly(Glu, Tyr) 4:1 as substrate incubated in presence of [gamma33P]ATP by image analyserMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90E+3nMAssay Description:In vitro inhibition of Syk phosphorylation in rat whole bloodMore data for this Ligand-Target Pair