Compile Data Set for Download or QSAR
maximum 50k data
Found 194 of kd data for polymerid = 1003
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  0.0530nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50312990((R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-...)
Affinity DataKd:  0.0530nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataKd:  8.30nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM24654(4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-...)
Affinity DataKd:  11nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM142598(US10238658, Example Reference | US10813932, Refere...)
Affinity DataKd:  24nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM142598(US10238658, Example Reference | US10813932, Refere...)
Affinity DataKd:  24nMAssay Description:The GSK3-α protein (500 ng/mL, 2.5 μL) was mixed with the test compound (2.5 μL at either 4 μg/mL, 0.4 μg/mL, 0.04 μg/m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM142598(US10238658, Example Reference | US10813932, Refere...)
Affinity DataKd:  24nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)
Affinity DataKd:  37nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)
Affinity DataKd:  37nMAssay Description:Binding constant for full-length GSK3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)
Affinity DataKd:  37nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  69nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  69nMAssay Description:Binding constant for full-length GSK3BMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705)
Affinity DataKd:  69nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataKd:  83nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataKd:  100nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM173196(4-(2-methoxyphenyl)-3,7,7-trimethyl-2,4,6,7,8,9-he...)
Affinity DataKd: <100nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataKd:  120nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50113707(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)
Affinity DataKd:  126nMAssay Description:Binding affinity to GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  148nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged GSK3B (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataKd:  230nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  230nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged GSK3B (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataKd:  350nMAssay Description:Binding constant for full-length GSK3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataKd:  350nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataKd:  350nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM15138(5-indazolyl pyridine 11g | 5-{5-[(2S)-2-amino-3-ph...)
Affinity DataKd:  350nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM303136(US10137122, Compound 8)
Affinity DataKd:  550nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM303137(US10137122, Compound 9)
Affinity DataKd:  550nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM188505(4-(2-fluorophenyl)-3,7,7-trimethyl-2,4,6,7,8,9-hex...)
Affinity DataKd:  550nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM303142(US10137122, Compound 14)
Affinity DataKd:  550nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM188503(3,7,7-trimethyl-4-(pyridin-3-yl)-2,4,6,7,8,9-hexah...)
Affinity DataKd:  550nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM188498(3,7,7-trimethyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-...)
Affinity DataKd:  550nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM303133(US10137122, Compound 5)
Affinity DataKd:  550nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM188504(3,7,7-trimethyl-4-(pyridin-4-yl)-2,4,6,7,8,9-hexah...)
Affinity DataKd:  550nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM188502(3,7,7-trimethyl-4-(pyridin-2-yl)-2,4,6,7,8,9-hexah...)
Affinity DataKd:  550nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50355499(CHEMBL1908395 | CHEMBL1908842)
Affinity DataKd:  720nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM31099(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S)-3-hydroxy...)
Affinity DataKd:  730nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd:  730nMAssay Description:Binding constant for full-length GSK3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd:  730nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  810nMAssay Description:Binding affinity to full-length human wild-type GSK-3-beta expressed in mammalian expression system assessed as dissociation constant by DiscoverX KI...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  950nMAssay Description:Binding constant for full-length GSK3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  950nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  950nMAssay Description:Binding constant for full-length GSK3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Affinity DataKd:  1.20E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Affinity DataKd:  1.20E+3nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Affinity DataKd:  1.20E+3nMAssay Description:The GSK3-α protein (500 ng/mL, 2.5 μL) was mixed with the test compound (2.5 μL at either 4 μg/mL, 0.4 μg/mL, 0.04 μg/m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM161376(US10238658, Example 1 | US10813932, Example 1 | US...)
Affinity DataKd:  1.20E+3nMAssay Description:The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataKd:  1.70E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding constant for full-length GSK3BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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