BDBM50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef
SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
InChI Key InChIKey=XZXHXSATPCNXJR-ZIADKAODSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 505 hits for monomerid = 50026612
Affinity DataKi: 3.80nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...More data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin
Curated by ChEMBL
The University of Texas At Austin
Curated by ChEMBL
Affinity DataKi: 5.60nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
Affinity DataKi: 5.90nMAssay Description:The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...More data for this Ligand-Target Pair
Affinity DataKi: 5.90nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...More data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA and 1 mM DTT. The inhibitory activities of compounds of the in...More data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...More data for this Ligand-Target Pair
Affinity DataKi: 113nMAssay Description:The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...More data for this Ligand-Target Pair
Affinity DataKi: 113nMAssay Description:Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...More data for this Ligand-Target Pair
Affinity DataKd: 3.20E+3nMAssay Description:Briefly, 5 mg of a protein mixture of the four cell lines or a single cell line were incubated with compound dilution series in DMSO (3 nM, 10 nM, 30...More data for this Ligand-Target Pair
Affinity DataKd: 5.90E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 340nMAssay Description:Binding constant for MET(M1250T) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 4.10nMAssay Description:Binding constant for TAK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 9.80nMAssay Description:Binding constant for RET(V804L) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.30E+3nMAssay Description:Binding constant for PAK7 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 280nMAssay Description:Binding constant for SIK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.30E+3nMAssay Description:Binding constant for MLK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK8 kinase domainMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MKNK1 kinase domainMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 3(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 2.10E+3nMAssay Description:Binding constant for MEK3 kinase domainMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PIK3CB kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 3.30E+3nMAssay Description:Binding constant for PAK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 640nMAssay Description:Binding constant for PRKD3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for NEK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 340nMAssay Description:Binding constant for ULK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MTOR kinase domainMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 240nMAssay Description:Binding constant for RIPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 180nMAssay Description:Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 36nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for BRAF kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for AKT1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for DMPK kinase domainMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PIP5K1C kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.50E+3nMAssay Description:Binding constant for ERK5 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Binding constant for CSNK1E kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 87nMAssay Description:Binding constant for LOK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TAOK3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 47nMAssay Description:Binding constant for KIT(D816V) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 8.5nMAssay Description:Binding constant for MERTK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 580nMAssay Description:Binding constant for SRC kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 29nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding constant for PAK3 kinase domainMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 1.80nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.90E+3nMAssay Description:Binding constant for WEE1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.30E+3nMAssay Description:Binding constant for CSNK1D kinase domainMore data for this Ligand-Target Pair