Reaction Details Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
Ligand
BDBM50080528
Substrate
n/a
Meas. Tech.
ChEMBL_153000 (CHEMBL759483)
Ki
187000±n/a nM
Citation
 Christner, C; Wyrwa, R; Marsch, S; Küllertz, G; Thiericke, R; Grabley, S; Schumann, D; Fischer, G Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J Med Chem 42:3615-22 (1999) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
Synonyms:
PIN4 | PIN4_HUMAN | PPIase Pin4 | Par14 | Parvulin 14 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 2 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 | Peptidyl-prolyl cis/trans isomerase EPVH | Rotamase Pin4 | hPar14
Type:
PROTEIN
Mol. Mass.:
13820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502606
Residue:
131
Sequence:
MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK
  
Inhibitor
Name:
BDBM50080528
Synonyms:
3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide | 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione | CHEMBL123292 | Cycloheximid | Zykloheximid | cid_6197 | cycloheximide | med.21724, Compound Cycloheximide
Type:
Small organic molecule
Emp. Form.:
C15H23NO4
Mol. Mass.:
281.3474
SMILES:
C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1 |r|
Structure:
Search PDB for entries with ligand similarity: