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Target
Procathepsin L
Ligand
BDBM50084650
Substrate
n/a
Meas. Tech.
ChEMBL_321690 (CHEMBL872185)
Ki
0.47±n/a nM
Citation
Marquis, RW; James, I; Zeng, J; Trout, RE; Thompson, S; Rahman, A; Yamashita, DS; Xie, R; Ru, Y; Gress, CJ; Blake, S; Lark, MA; Hwang, SM; Tomaszek, T; Offen, P; Head, MS; Cummings, MD; Veber, DF Azepanone-based inhibitors of human cathepsin L. J Med Chem 48:6870-8 (2005) [PubMed] Article
More Info.:
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Inhibitor
Name:
BDBM50084650
Synonyms:
CHEMBL177914 | {(S)-1-[(S)-1-Formyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester | {1-[1-Formyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester(Cbz-Phe-Tyr-CHO)
Type:
Small organic molecule
Emp. Form.:
C26H26N2O5
Mol. Mass.:
446.495
SMILES:
Oc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)C=O)cc1