Target
Dipeptidyl peptidase 1
Ligand
BDBM50418000
Substrate
n/a
Meas. Tech.
ChEMBL_719162 (CHEMBL1679621)
IC50
158.49±n/a nM
Citation
 Lainé, DPalovich, MMcCleland, BPetitjean, EDelhom, IXie, HDeng, JLin, GDavis, RJolit, ANevins, NZhao, BVilla, JSchneck, JMcDevitt, PMidgett, RKmett, CUmbrecht, SPeck, BDavis, ABBettoun, D Discovery of novel cyanamide-based inhibitors of cathepsin C. ACS Med Chem Lett 2:142-147 (2011) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 1
Synonyms:
CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:
Enzyme
Mol. Mass.:
51857.28
Organism:
Homo sapiens (Human)
Description:
P53634
Residue:
463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
  
Inhibitor
Name:
BDBM50418000
Synonyms:
CHEMBL1672432
Type:
Small organic molecule
Emp. Form.:
C12H14BrN3O2S
Mol. Mass.:
344.227
SMILES:
C[C@H]1C[C@H](CN1C#N)NS(=O)(=O)c1cccc(Br)c1 |r|
Structure:
Search PDB for entries with ligand similarity: