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Found 1113 with Last Name = 'villa' and Initial = 'j'
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50514737(CHEMBL4482861)
Affinity DataKi:  0.0417nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50514738(CHEMBL4536304)
Affinity DataKi:  0.0537nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50514722(CHEMBL4438801)
Affinity DataKi:  0.0661nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM50354086(FK-228 | Istodax | ROMIDEPSIN)
Affinity DataKi:  0.150nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50514727(CHEMBL4483022)
Affinity DataKi:  0.324nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50103072(1-Benzyl-2-piperazin-1-yl-1H-benzoimidazole | CHEM...)
Affinity DataKi:  0.620nMAssay Description:Binding affinity towards rat 5-hydroxytryptamine 3 receptor was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50514724(CHEMBL4535472)
Affinity DataKi:  0.977nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051232(8-(4-Fluoro-benzyl)-2-furan-2-yl-8H-pyrazolo[4,3-e...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051234(2-(furan-2-yl)-8-phenethyl-8H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards rat 5-hydroxytryptamine 3 receptor was evaluatedMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50094688(2-(furan-2-yl)-8-isopentyl-8H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50048466(2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051241(2-(furan-2-yl)-7-(3-phenylpropyl)-7H-pyrazolo[4,3-...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051242(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]tria...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403490(CHEMBL312157)
Affinity DataKi:  2.80nMAssay Description:Inhibitory activity of compound against FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50514745(CHEMBL4439953)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051232(8-(4-Fluoro-benzyl)-2-furan-2-yl-8H-pyrazolo[4,3-e...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50019848(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in post-mortem human brain frontal cortex membrane measured after 30 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50514739(CHEMBL4467833)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051234(2-(furan-2-yl)-8-phenethyl-8H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051228(2-Furan-2-yl-7-(2-morpholin-4-yl-ethyl)-7H-pyrazol...)
Affinity DataKi:  5.60nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50094688(2-(furan-2-yl)-8-isopentyl-8H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  5.60nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataKi:  6.40nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  7nMAssay Description:Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50514718(CHEMBL4438158)
Affinity DataKi:  7.80nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant HDAC1 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051227(7-Butyl-2-furan-2-yl-7H-pyrazolo[4,3-e][1,2,4]tria...)
Affinity DataKi:  8.90nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50108391(4-Amino-5-chloro-2-methoxy-benzoic acid 2-methyl-2...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards 5-HT4 receptor in striatum membranes of guinea-pig brain was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50108391(4-Amino-5-chloro-2-methoxy-benzoic acid 2-methyl-2...)
Affinity DataKi:  11.2nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant HDAC3 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051237(2-Furan-2-yl-7-(2-methyl-butyl)-7H-pyrazolo[4,3-e]...)
Affinity DataKi:  12nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  12nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051226(7-(4-Fluoro-benzyl)-2-furan-2-yl-7H-pyrazolo[4,3-e...)
Affinity DataKi:  12nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant HDAC11 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50108388(4-Amino-5-chloro-2-methoxy-benzoic acid 2-methyl-2...)
Affinity DataKi:  13.8nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM50377384(AZUMAMIDE C)
Affinity DataKi:  14nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50108388(4-Amino-5-chloro-2-methoxy-benzoic acid 2-methyl-2...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051235(2-Furan-2-yl-7-(4-phenyl-butyl)-7H-pyrazolo[4,3-e]...)
Affinity DataKi:  21nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant HDAC6 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051238(2-Furan-2-yl-7-[2-(4-isobutyl-phenyl)-ethyl]-7H-py...)
Affinity DataKi:  22nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051230(2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1...)
Affinity DataKi:  22.6nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051240(2-Furan-2-yl-7-phenyl-7H-pyrazolo[4,3-e][1,2,4]tri...)
Affinity DataKi:  22.7nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM50372469(AZUMAMIDE E)
Affinity DataKi:  25nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051242(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]tria...)
Affinity DataKi:  30.4nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  40nMAssay Description:Inhibition of human recombinant HDAC10 using Ac-Arg-His-Lys(Ac)-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50514734(CHEMBL4568994)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403488(CHEMBL81439)
Affinity DataKi:  68nMAssay Description:Inhibitory activity of compound against FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50051229(2-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]tria...)
Affinity DataKi:  77.7nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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