Affinity DataKi: 0.0417nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.0537nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.0661nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark
Curated by ChEMBL
Technical University Of Denmark
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.324nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.620nMAssay Description:Binding affinity towards rat 5-hydroxytryptamine 3 receptor was evaluatedMore data for this Ligand-Target Pair
Affinity DataKi: 0.977nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Binding affinity towards rat 5-hydroxytryptamine 3 receptor was evaluatedMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 2.80nMAssay Description:Inhibitory activity of compound against FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
University Of Barcelona
Curated by ChEMBL
University Of Barcelona
Curated by ChEMBL
Affinity DataKi: 4.5nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in post-mortem human brain frontal cortex membrane measured after 30 mins by liquid sc...More data for this Ligand-Target Pair
Affinity DataKi: 4.5nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 5.60nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 5.60nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 6.40nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 7.80nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human recombinant HDAC1 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 8.90nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Binding affinity towards 5-HT4 receptor in striatum membranes of guinea-pig brain was evaluatedMore data for this Ligand-Target Pair
Affinity DataKi: 11.2nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human recombinant HDAC3 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark
Curated by ChEMBL
Technical University Of Denmark
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of human recombinant HDAC11 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 13.8nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark
Curated by ChEMBL
Technical University Of Denmark
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Inhibition of human recombinant HDAC6 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 22.6nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 22.7nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark
Curated by ChEMBL
Technical University Of Denmark
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 30.4nMAssay Description:Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat whole brain homogenates.More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Technical University Of Denmark
Curated by ChEMBL
Technical University Of Denmark
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Inhibition of human recombinant HDAC10 using Ac-Arg-His-Lys(Ac)-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 68nMAssay Description:Inhibitory activity of compound against FK506 binding protein 12 was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 77.7nMAssay Description:Inhibition of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal homogenates.More data for this Ligand-Target Pair