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Target
Receptor protein-tyrosine kinase
Ligand
BDBM276743
Substrate
n/a
Meas. Tech.
Human, Dog and Rat c-Fms Enzyme Assay
IC50
16.0±n/a nM
Citation
 Chen, J; Donahue, M; Lim, H; Lin, R; Salter, R; Wu, J; Gong, Y Substituted pyridine derivatives useful as C-FMS kinase inhibitors US Patent  US10800764 Publication Date 10/13/2020 
Target
Name:
Receptor protein-tyrosine kinase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
151541.18
Organism:
Dog
Description:
Q2XPT7
Residue:
1355
Sequence:
MESKALLAIALWLCVETGAASGGLPSVSLHPPRLSIQKDILTIMANTTLQITCRGQRDLDWLWPNNQSGSEKRVEVTECSDSFFCKMLTIPKVMGNDTGAYKCFYRDTDMASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYKIYDVILSPPHGVELSVGERLVLNCTVRTELNVGLDFNWEYPSLKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGWYTCAASSGLMTKRNSTFIRVHEKPFVAFGSGMESSVEATVGDRVRIPVKYLGYPPPEIKWYKNGRPIESNHTIKVGHVLTIMEVSEKDTGNYTVILTNPISKEKQSHVISLVVNVPPQIGEKSLISPVDSYQYGTTQSLTCTVYAVPPPHHIRWYWQLEECAYKPAQAVLMTNPYTCKEWRNVDDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVIRGPEITLQPDTQPTEQESVSLWCTADRTTFENLTWYKSGPQALAVHAGEVPTPVCKNLDALWRMNATTFSNGTSDILILELQNVSLQDQGDYVCFAQDRKTKKRHCVVRQLTVLERVAPMITGNLENQTTSIGETIEVSCTTSGNPPPQITWFKDNETLVEDSGIILKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIVEGAQEKTNLEVIILVGTAVIAMFFWLLLVIVLRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKEYVGEITMDPKRRLDSITSSQSSASSGFVEEKSLSDVEEEEVSEDLYKNFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPNQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLAPSFSGLMPSKSKESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLMEIGPQAGSAAQILQPDSGPTLSSPPV
  
Inhibitor
Name:
BDBM276743
Synonyms:
US10071991, Compound (P) | US10800764, Compound (P) | US11214566, Compound (P) | US9611259, Compound (P)
Type:
Small organic molecule
Emp. Form.:
C27H35N5O2
Mol. Mass.:
461.5991
SMILES:
CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1 |c:5|
Structure:
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