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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM479308
Substrate
n/a
Meas. Tech.
Orexin Receptor Cell-Based Functional Assay
IC50
3.00±n/a nM
Citation
 Kamenecka, TM; Holenz, J; Wesolowski, S; He, Y; Bürli, R Halo-substituted piperidines as orexin receptor modulators US Patent  US10894789 Publication Date 1/19/2021 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM479308
Synonyms:
US10894789, Compound 264
Type:
Small organic molecule
Emp. Form.:
C22H22F6N8O
Mol. Mass.:
528.4535
SMILES:
C[C@@H]1CC(F)(F)CN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)c(C)c1-c1ncc(F)cn1 |r|
Structure:
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