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TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50123453(CHEMBL3623290)
Affinity DataIC50: 50nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2016
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366395(CHEMBL4175869)
Affinity DataIC50: 60nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366411(CHEMBL4160749)
Affinity DataIC50: 62nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366399(CHEMBL4168669)
Affinity DataIC50: 73nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366379(CHEMBL4165249)
Affinity DataIC50: 87nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366426(CHEMBL4161819)
Affinity DataIC50: 93nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366435(CHEMBL4161400)
Affinity DataIC50: 120nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366394(CHEMBL4159065)
Affinity DataIC50: 180nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM85509(NSC_5472 | CAS_55142-85-3 | Ticlopidine)
Affinity DataKi:  200nMAssay Description:Mechanism based inhibition of human cytochrome P450 2B6 measured by bupropion hydroxylation using human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM85509(NSC_5472 | CAS_55142-85-3 | Ticlopidine)
Affinity DataIC50: 210nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366407(CHEMBL4169324)
Affinity DataIC50: 230nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKi:  340nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion 4-hydroxylation after 15 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366401(CHEMBL4169721)
Affinity DataIC50: 370nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKi:  400nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as efavirenz 8-hydroxylation after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50397662(CLOPIDOGREL)
Affinity DataKi:  500nMAssay Description:Mechanism based inhibition of human cytochrome P450 2B6 using human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50397662(CLOPIDOGREL)
Affinity DataKi:  500nMAssay Description:Time dependent inhibition of CYP2B6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50088447(CHEBI:223316 | (+)-Artemisinin)
Affinity DataEC50:  600nMAssay Description:Induction of CYP2B6 in human hepatocytes after 72 hrs relative to vehicle-treated controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM85509(NSC_5472 | CAS_55142-85-3 | Ticlopidine)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human CYP2B6 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50318484(CHEMBL190461 | 2-((1R,6R)-6-Isopropenyl-3-methyl-c...)
Affinity DataKi:  690nMAssay Description:Mixed type inhibition of human recombinant CYP2B6 expressed in baculovirus-infected insect cells using coumarin as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50614709(CHEMBL5273615)
Affinity DataIC50: 780nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 790nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as 8-hydroxyefavirenz 14-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM85509(NSC_5472 | CAS_55142-85-3 | Ticlopidine)
Affinity DataKi:  800nMAssay Description:Mechanism based inhibition of human cytochrome P450 2B6 measured by bupropion hydroxylation using recombinant CYP2B6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50187243(ethinyloestradiol | 17alpha-ethynylestra-1,3,5(10)...)
Affinity DataKi:  800nMAssay Description:Mechanism based inhibition of human cytochrome P450 2B6 measured by 7-EFC O-deethylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366393(CHEMBL4176100)
Affinity DataIC50: 850nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50187243(ethinyloestradiol | 17alpha-ethynylestra-1,3,5(10)...)
Affinity DataKi:  900nMAssay Description:Mechanism based inhibition of human cytochrome P450 2B6 measured by 7-EFC O-deethylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataKi:  900nMAssay Description:Mechanism based inhibition of human cytochrome P450 2B6 measured by 7-EFC O-deethylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380508(CHEMBL2018923)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50397662(CLOPIDOGREL)
Affinity DataKi:  1.10E+3nMAssay Description:Mechanism based inhibition of human cytochrome P450 2B6 using recombinant CYP2B6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion 4-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366403(CHEMBL4164142)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418085(CHEMBL1743344)
Affinity DataKi:  1.20E+3nMAssay Description:Mechanism based inhibition of human cytochrome P450 2B6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366334(CHEMBL4173133)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50532215(CBD-V | CBDV | Cannabidivarin | GWP42006)
Affinity DataKi:  1.30E+3nMAssay Description:Mixed inhibition of recombinant CYP2B6 (unknown origin) using coumarin as substrate in presence of NADPH-generating system by Lineweaver-burk plots a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50370232(BA-41166E | L-5103 | Rifadin | Rifampicin | RIFAMP...)
Affinity DataEC50:  1.30E+3nMAssay Description:Induction of CYP2B6 activity in human donor hepatocytes assessed as hydroxybupropion formation after 48 hrs by LC/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as efavirenz 8-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50577263(CHEMBL4850236)
Affinity DataEC50:  1.90E+3nMAssay Description:Induction of CYP2B6 in human hepatocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using 8-hydroxyefavirenz as probe after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380510(CHEMBL2018925)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM520(ABT-538 | Norvir | CHEMBL163 | 1,3-thiazol-5-ylmet...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human CYP2B6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418086(Thioplex | THIOTEPA)
Affinity DataKi:  2.20E+3nMAssay Description:Mechanism based inhibition of human cytochrome P450 2B6 measured by bupropion hydroxylation using a recombinant systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM668001(US20240124434, Compound S5-A)
Affinity DataIC50: 2.49E+3nMAssay Description:CYP inhibition by test compounds in human liver microsomes (HLM) for seven major CYP450 isoforms CYP1A2, CYP2C9, CYP2D6, CYP2B6, CYP2C8, CYP2C19 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265079(CHEMBL496942 | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLP...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin) using bupropion substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50061117(6,6,9-Trimethyl-3-pentyl-6H-benzo[c]chromen-1-ol(C...)
Affinity DataKi:  2.55E+3nMAssay Description:Inhibition of recombinant human CYP2B6 using coumarin as substrate preincubated with NADPH for 20 mins and measured after 30 min by Lineweaver-burk p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50234041(US9765018, Example 116 | CHEMBL4060679)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50234039(US9765018, Example 115 | CHEMBL4082553)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50234040(US9765018, Example 114 | CHEMBL4060089)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2019
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366398(CHEMBL4164113)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50594408(CHEMBL5195440)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366406(CHEMBL4174365)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366414(CHEMBL4172017)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
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