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TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626248(CHEMBL106871)
Affinity DataIC50: 1nMAssay Description:Inhibition of human nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626248(CHEMBL106871)
Affinity DataKd:  1nMAssay Description:Inhibition of human nNOS assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50330882(CHEMBL1277951 | CHEMBL594682 | N1-((3R,4R)-4-((6-a...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50095181(N-(3-Aminomethyl-phenyl)-furan-2-carboxamidine | C...)
Affinity DataKi:  6nMAssay Description:Inhibition of human nNOS assessed as reduction of L-[14C]arginine to L-[14C]-citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50095181(N-(3-Aminomethyl-phenyl)-furan-2-carboxamidine | C...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50065807(N-(3-Aminomethyl-phenyl)-furan-2-carboxamidine | C...)
Affinity DataKi:  6.30nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50095172(N-(3-Aminomethyl-phenyl)-thiophene-2-carboxamidine...)
Affinity DataKi:  8.70nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50065843(CHEMBL555715 | CHEMBL553081 | N-(3-Aminomethyl-phe...)
Affinity DataKi:  8.70nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091817(CHEMBL302657 | 4-Methyl-6-propylpyridin-2-amine, 7...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50446250(CHEMBL3109188 | US9732037, Compound 9)
Affinity DataKi:  10nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271363(N-(3-Aminomethyl-phenyl)-2-methylsulfanyl-acetamid...)
Affinity DataKi:  11nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271464(N-(3-Aminomethyl-phenyl)-2-fluoro-acetamidine | CH...)
Affinity DataKi:  11nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50065823(N-(3-Aminomethyl-phenyl)-2-methylsulfanyl-acetamid...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50065813(N-(3-Aminomethyl-phenyl)-2-fluoro-acetamidine | CH...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50363262(CHEMBL1944717)
Affinity DataIC50: 12nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM190667(nNOS inhibitor, 5 | US10759791, Compound 14j)
Affinity DataKi:  13nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM190667(nNOS inhibitor, 5 | US10759791, Compound 14j)
Affinity DataKi:  13nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM190667(nNOS inhibitor, 5 | US10759791, Compound 14j)
Affinity DataKi:  13nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM190667(nNOS inhibitor, 5 | US10759791, Compound 14j)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM111496(US8618286, 22)
Affinity DataIC50: 14nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50330882(CHEMBL1277951 | CHEMBL594682 | N1-((3R,4R)-4-((6-a...)
Affinity DataKi:  14nMAssay Description:Recombinant NOS isozymes over-expressed in E. coli were utilized. (Ji, H., et al., Discovery of highly potent and selective inhibitors of neuronal ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50225106(NG-nitroarginine | 2-Amino-5-(N'-nitro-guanidino)-...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50062133(4-Methyl-piperidin-(2Z)-ylideneamine | 4-Methyl-pi...)
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271882(2-{2-[4-(2-CARBAMIMIDOYLSULFANYL-ETHYL)-PHENYL]-ET...)
Affinity DataKi:  16nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50330883(CHEMBL1277952 | CHEMBL1233715 | N1-((3R,4S)-4-((6-...)
Affinity DataKi:  17.7nMAssay Description:Recombinant NOS isozymes over-expressed in E. coli were utilized. (Ji, H., et al., Discovery of highly potent and selective inhibitors of neuronal ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50620565(CHEMBL5420690)
Affinity DataKi:  19nMAssay Description:Inhibition of human nNOS expressed in Escherichia coli using human oxyhemoglobin by hemoglobin (Hb) NO capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM344410(US9783500, Compound 6 | US9783500, Compound 18)
Affinity DataKi:  19nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50352593(CHEMBL1825174)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50258602(CHEMBL4068062)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant human nNOS expressed in Escherichia coli using L-arginine as substrate after 30 secs by hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50258601(CHEMBL4089246)
Affinity DataKi:  21nMAssay Description:Inhibition of recombinant human nNOS expressed in Escherichia coli using L-arginine as substrate after 30 secs by hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM344409(US9783500, Compound 5)
Affinity DataKi:  21nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)
Affinity DataKi:  21nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50592473(CHEMBL5191295)
Affinity DataKi:  21nMAssay Description:Inhibition of human nNOS using L-arginine as substrate assessed as reduction in NO production in the presence of NADPH by NO-hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50526361(CHEMBL4532683)
Affinity DataKi:  21nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50526373(CHEMBL4590333)
Affinity DataKi:  23nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091817(CHEMBL302657 | 4-Methyl-6-propylpyridin-2-amine, 7...)
Affinity DataIC50: 23nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50014717(CHEMBL3262026 | US9951014, Name 8R | US10759791, C...)
Affinity DataKi:  24nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5 microplate reader. IC50 values for each comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50255363(N1-{(+/-)-4'-[(6''-amino-4''-methylpyridin-2''-yl)...)
Affinity DataKi:  24nMAssay Description:Recombinant NOS isozymes over-expressed in E. coli were utilized. (Ji, H., et al., Discovery of highly potent and selective inhibitors of neuronal ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM344412(US9783500, Compound 7)
Affinity DataKi:  25nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50341682(NOS Inhibitor, 3j | 6,6'-(pyridine-3,5-diyldiethan...)
Affinity DataKi:  25nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5 microplate reader. IC50 values for each comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50341682(NOS Inhibitor, 3j | 6,6'-(pyridine-3,5-diyldiethan...)
Affinity DataKi:  25nMAssay Description:Inhibition assay using nitric oxide synthases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50446252(CHEMBL3109186 | US9732037, Compound 6)
Affinity DataKi:  26nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM111497(US8618286, 23)
Affinity DataIC50: 28nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50271829(2-Propyl-isothiourea | CHEMBL483092)
Affinity DataKi:  29nMAssay Description:Inhibition of nNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50592474(CHEMBL5189279)
Affinity DataKi:  29nMAssay Description:Inhibition of human nNOS using L-arginine as substrate assessed as reduction in NO production in the presence of NADPH by NO-hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50055281(2-Ethyl-isothiourea | S-ethyl-iso-thiourea | S-ETH...)
Affinity DataKi:  29nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50526363(CHEMBL4440481)
Affinity DataKi:  29nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50250568(CHEMBL4094689)
Affinity DataKi:  30nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50258687(CHEMBL4092027)
Affinity DataKi:  30nMAssay Description:Inhibition of recombinant human nNOS expressed in Escherichia coli using L-arginine as substrate after 30 secs by hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50258687(CHEMBL4092027)
Affinity DataKi:  30nMAssay Description:Inhibition of human nNOS expressed in Escherichia coli expression system assessed as reduction in NO production in presence of L-arginine measured fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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