Compile Data Set for Download or QSAR
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Report error Found 104 of affinity data for UniProtKB/TrEMBL: Q8NE63
TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172243(CHEMBL3103192)
Affinity DataIC50:  40nMAssay Description:Inhibition of Hipk4 (unknown origin) by quantitative PCRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM17055((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  100nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataIC50:  100nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  100nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563891(CHEMBL4793380)
Affinity DataIC50:  127nMAssay Description:Inhibition of human HIPK4 using RRRFRPASPLRGPPK as substrate after 40 mins by [gamma-33ATP] radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  138nMAssay Description:Inhibition of human HIPK4 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50506351(CHEMBL4439133)
Affinity DataIC50:  176nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged HIPK4 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  314nMAssay Description:Inhibition of human HIPK4 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50526803(CHEMBL4434871 | US10870651, Compound 101)
Affinity DataIC50:  550nMAssay Description:Compounds of the invention were assayed for activity against a variety of different kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50:  620nMAssay Description:Inhibition of human HIPK4 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  650nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM311210((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50604138(CHEMBL5184381)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50631397(CHEMBL5432402)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HIPK4 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant full length HIPK4 using RRRFRPASPLRGP as substrate after 40 mins by [gamma-33ATP] radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50499634(CHEMBL3741589)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HIPK4 using MBP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of [3H]CGP12177 from beta1 adrenoreceptor in Rattus norvegicus (rat) cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50326053(CHEMBL608533 | PKC-412 | US20240132489, Compound S...)
Affinity DataKd:  950nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  150nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  150nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  390nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50326053(CHEMBL608533 | PKC-412 | US20240132489, Compound S...)
Affinity DataKd:  950nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKd:  2.70nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataKd:  160nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)
Affinity DataKd:  320nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM13535(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Affinity DataKd:  400nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataKd:  220nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  970nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM17055((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM27817(2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  3.60E+3nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM26300(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...)
Affinity DataKd:  97nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM36409(2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin...)
Affinity DataKd:  2.20E+3nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  0.510nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHomeodomain-interacting protein kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataKd:  310nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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