Search by Compound Name

Compound Name:

Compounds Sorted by Binding Data per Compound

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55
56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81
82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105
106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124
125 127 128 129 130 132 133 134 135 136 137 138 139 140 141 143 144 145 146
147 148 149 150 151 153 154 155 156 159 160 161 163 164 165 168 170 171 173
174 176 178 179 183 184 186 188 189 190 191 192 193 196 198 199 200 203 204
205 206 207 208 209 210 216 220 224 226 227 229 232 237 238 241 243 248 252
253 259 261 270 274 276 277 285 291 303 304 313 318 323 325 328 333 335 337
339 341 353 360 361 365 389 393 398 401 413 433 442 444 445 446 447 448 451
453 454 455 457 458 460 463 465 467 473 477 478 482 484 499 504 505 506 517
521 525 543 549 551 554 591 606 663 691 708 796 804 821 825 833 842 847 854
855 861 873 879 883 887 913 914 925 926 938 947 1010 1027 1050 1052 1081 1082
1099 1115 1130 1133 1206 1262 1543 1639 1903 2029
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Enz. Inhib. Data
ITC Data
Binding Targets
Alternate Compound Names
14 IC50
  • JAK1 (aa 850-1154)
  • JAK2 (aa 808-1132)
  • JAK3 (aa 781-1124)
  • Non-receptor tyrosine-protein kinase TYK2
  • TYK2 (aa 871-1187)
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US10206907, Compound 18
  • US8563545, 2
8 IC50 6 Kd
  • Death-associated protein kinase 1
  • Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2)
  • Interleukin-1 receptor-associated kinase 4
  • Myosin light chain kinase, smooth muscle
  • Rho-associated protein kinase 2
  • Serine/threonine-protein kinase pim-1
  • Serine/threonine-protein kinase pim-2
  • Serine/threonine-protein kinase pim-3
  • HS38
14 IC50
  • Serine/threonine-protein kinase PIM-3
  • Serine/threonine-protein kinase pim-1
  • Serine/threonine-protein kinase pim-2
  • US8575145, 46/47/48/49/50
  • US8575145, 77
  • US8575145, 78
  • US8575145, 79
  • US8575145, 80
14 IC50
  • Acetylcholinesterase
  • Carboxylic ester hydrolase
  • Cholinesterases
  • (-)-Phenserine
  • (3aS)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-phenylcarbamate
  • CHEMBL54727
14 IC50
  • HIV-1 Integrase
  • Human immunodeficiency virus type 1 integrase
  • Integrase
  • (2Z)-4-[3,5-bis(benzyloxy)phenyl]-2-hydroxy-4- oxobut-2-enoic acid (Compound 2)
  • CHEMBL19977
  • CHEMBL320261
5 Ki 9 IC50
  • 1,3-beta-glucan synthase component GLS2
  • 5-hydroxytryptamine receptor 1A
  • Alpha-1A adrenergic receptor
  • Axin-1/Glycogen synthase kinase-3 beta
  • Cytochrome P450 3A
  • Dopamine receptor
  • Mitogen-activated protein kinase kinase kinase kinase 4
  • Serine/threonine-protein kinase pim-1
  • Serine/threonine-protein kinase pim-2
  • Serine/threonine-protein kinase pim-3
  • US8614206, 139
4 Ki 8 IC50 2 Kd
  • Casein kinase II alpha/beta
  • Casein kinase II subunit alpha
  • Dual-specificity tyrosine-phosphorylation regulated kinase 1A
  • Hepatitis C virus serine protease, NS3/NS4A
  • Ribosyldihydronicotinamide dehydrogenase [quinone]
  • 4,5,6,7-tetrabromo-1H-1,2,3-benzotriazole
  • 4,5,6,7-tetrabromo-1H-benzotriazole (14)
  • CHEMBL177820
  • TBB
11 Ki 3 IC50
  • 72 kDa type IV collagenase
  • Bone morphogenetic protein 1
  • Carbonic Anhydrase IV
  • Carbonic anhydrase 1
  • Carbonic anhydrase 2
  • Collagenase (ChC)
  • Interstitial collagenase
  • Matrix metalloproteinase-9
  • Meprin A subunit beta
  • Neutrophil collagenase
  • Stromelysin-1
  • 2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyacetamide
  • CGS 27023A Analog 22
  • Hydroxamate 12
14 IC50
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • US8653092, 1
14 IC50
  • PI3-kinase class I
  • Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR
  • Phosphatidylinositol 3-kinase regulatory subunit beta
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  • US9682141, 529
  • US9682141, 54
14 Ki
  • Prokineticin receptor 1 (PRK1)
  • Prokineticin receptor 2 (PRK2)
  • US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
  • US8722896, (+/-)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
  • US8722896, (-)-(2R)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
3 Ki 11 IC50
  • Cytochrome P450 2A6
  • Cytochrome P450 2B6
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 2E1
  • Cytochrome P450 3A
  • 3-(3-methylthiophen-2-yl)pyridine
  • CHEMBL179669
  • US8609708, 4
  • nicotine 3-heteroaromatic analogue 4
5 Ki 8 IC50
0 ΔG°
  • Farnesyl Diphosphate Synthase (FPPS)
  • Farnesyl diphosphate synthase
  • Farnesyl pyrophosphate synthase
  • Geranylgeranyl Diphosphate Synthase (GGPPS)
  • Hypoxanthine-guanine phosphoribosyltransferase
  • (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
  • Bisphosphonate 6
  • CHEMBL834
  • JMC515594 Compound 62
14 IC50
  • Metabotropic glutamate receptor 1
  • Metabotropic glutamate receptor 5
  • US8853203, 88
  • US9650377, Example 88j
11 Ki 3 IC50
  • Protein-Tyrosine Phosphatase 1B (PTP1B)
  • Protein-tyrosine phosphatase 1B
  • Tyrosine-protein phosphatase non-receptor type 2
  • 5-{2-fluoro-5-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]prop-1-en-1-yl]phenyl}-1,2-oxazole-3-carboxylic acid
  • CHEMBL117869
  • Isoxazole carboxylic acid analog 1
14 IC50
  • Cyclin-dependent kinase 2
  • Glycogen synthase kinase-3
  • Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Mitogen-activated protein kinase 10
  • RAC-alpha serine/threonine-protein kinase
  • Rho-associated protein kinase 1
  • Rho-associated protein kinase 2
  • Ribosomal protein S6 kinase alpha 1
  • Ribosomal protein S6 kinase alpha 5
  • Serine/threonine-protein kinase AKT
  • Serine/threonine-protein kinase AKT2
  • Serine/threonine-protein kinase PLK1
  • Aminofurazanyl-azabenzimidazole 6n
  • N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide
14 Ki
  • Coagulation factor X
  • Hepsin
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Trypsin-1
  • Urokinase (uPA) Mutant (S190A)
  • Urokinase-type plasminogen activator
  • 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phenylbenzen-1-olate
  • 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-1,1-BIPHENYL-2-OLATE)
  • APC-8696
  • CA-04
  • CRA-8696
14 Ki
  • Coagulation factor X
  • Hepsin
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Trypsin-1
  • Urokinase (uPA) Mutant (S190A)
  • Urokinase-type plasminogen activator
  • 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE
  • APC-10302
  • CA-14
  • CRA-10302
  • {amino[6-chloro-2-(2-hydroxy-3-phenylphenyl)-1H-indol-5-yl]methylidene}azanium
4 Ki 10 IC50
  • Beta-secretase 1
  • Potassium voltage-gated channel subfamily H member 2
  • US8975415, RP200
  • US8975415, RP202
  • US9242973, RP202
14 IC50
  • C-X-C chemokine receptor type 1
  • C-X-C chemokine receptor type 2
  • C5a anaphylatoxin chemotactic receptor (C5aR)
  • Platelet activating factor receptor
  • fMet-Leu-Phe receptor
  • US8981106, 1 (SX-517)
  • USRE47267, Compound 1
1 Ki 13 IC50
  • Cyclin-dependent kinase 1
  • Dual specificity mitogen-activated protein kinase kinase 2
  • Epidermal growth factor receptor
  • Heat shock protein beta-1
  • Mitogen-activated protein kinase 14
  • Mitogen-activated protein kinase 8
  • Mitogen-activated protein kinase 9
  • PKC alpha and beta-2
  • Protein kinase C alpha type
  • RAF proto-oncogene serine/threonine-protein kinase
  • Tyrosine-protein kinase Lck
  • 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-2-methoxypyrimidine
  • 4-[4-(4-fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]-2-methoxypyrimidine
  • CHEMBL95692
  • SB-242235
  • SB242235
14 IC50
  • ALK tyrosine kinase receptor
  • Aurora kinase A/Targeting protein for Xklp2
  • Aurora kinase B
  • Insulin receptor
  • Insulin-like growth factor I receptor
  • US10081622, Compound 18
  • US9029356, 18
  • US9255087, 18
  • US9616059, 18
6 Ki 8 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • P2X7 rat
  • US10047092, 3
  • US10053463, 3
  • US9040534, 3
6 Ki 8 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • P2X7 rat
  • US10047092, 17
  • US10053463, 17
  • US9040534, 17
6 Ki 8 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • P2X7 rat
  • US10047092, 18
  • US10053463, 18
  • US9040534, 18
6 Ki 8 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • P2X7 rat
  • US10047092, 23
  • US10053463, 23
  • US9040534, 23
6 Ki 8 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • P2X7 rat
  • US10047092, 28
  • US10053463, 28
  • US9040534, 28
6 Ki 8 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • P2X7 rat
  • US10047092, 29
  • US10053463, 29
  • US9040534, 29
6 Ki 8 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • P2X7 rat
  • US10047092, 30
  • US10053463, 30
  • US9040534, 30
6 Ki 8 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • P2X7 rat
  • US10047092, 93
  • US10053463, 93
  • US9040534, 93
14 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • US10124003, Ex. Compound 9
  • US10835536, Ex. Comp 9
  • US10894048, Ex Comp 51
  • US9108973, 9
14 IC50
  • Renal Outer Medullary Potassium (ROMK)
  • US9062070, 2A
  • US9062070, 2B
  • US9062070, 2C
  • US9062070, 2D
  • US9062070, 2E
  • US9062070, 2F
  • US9062070, 2G
  • US9062070, 2H
14 Ki
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • US9062078, 206
  • US9475819, 231
  • US9637496, 231
  • US9695183, 206
  • US9695183, 231
14 Ki
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • US9062078, 222
  • US9475819, 226
  • US9637496, 226
  • US9695183, 222
  • US9695183, 226
14 Ki
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • US9062078, 223
  • US9475819, 228
  • US9637496, 228
  • US9695183, 223
  • US9695183, 228
14 Ki
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • US9062078, 224
  • US9475819, 227
  • US9637496, 227
  • US9695183, 224
  • US9695183, 227
4 Ki 10 IC50
  • Acetylcholinesterase
  • Aldose Reductase (ALR2) Mutant (C298A/W219Y)
  • Aldose reductase (AR)
  • Alpha-glucosidase MAL62
  • Beta amyloid A4 protein
  • Beta-ketoacyl-ACP synthase III (FabH)
  • Dihydroorotate dehydrogenase (fumarate)
  • Histone deacetylase
  • Hydroxycarboxylic acid receptor 2
  • Tankyrase 1/2
  • Tyrosinase
  • Xanthine dehydrogenase
  • (2E)-3-phenylprop-2-enoic acid
  • CHEMBL27246
  • Cinnamic acid
  • Zimtsaeure
  • Zimtsaeure | trans-Cinnamate
  • t-Cinnamic acid
  • trans-Cinnamate
14 IC50
  • Cytoplasmic tyrosine-protein kinase BMX
  • Receptor protein-tyrosine kinase erbB-4
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase ITK/TSK
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase TEC
  • Tyrosine-protein kinase TXK
  • US10604504, Example 34
  • US9688629, 34
  • US9802915, Example 34
  • US9920031, Example 34
14 IC50
  • MAP kinase p38
  • Mitogen-activated protein kinase 10
  • Mitogen-activated protein kinase 14
  • Mitogen-activated protein kinase 3
  • Non-receptor tyrosine-protein kinase TYK2
  • Proto-oncogene tyrosine-protein kinase Src
  • Tyrosine-protein kinase Fyn
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • Tyrosine-protein kinase Lck
  • Tyrosine-protein kinase Lyn
  • 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(piperidin-4-yl)-1,2,3,4-tetrahydroquinazolin-2-one
  • CHEMBL319556
  • Dihydro-quinazolinone analog, 9
14 IC50
  • Cytochrome P450 3A
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10323032, Example 88
  • US9096596, 88
  • US9604982, Example 88
8 IC50 6 EC50
  • Aminopeptidase
  • Methionine Aminopeptidase (MAP)
  • Methionine Aminopeptidase Type 1 (MetAP1)
  • Methionine aminopeptidase 1
  • Methionine aminopeptidase 2
  • CHEMBL327579
  • pyridine-2-carboxylic acid inhibitor, 1
  • tert-butyl N-[2-(1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl]carbamate
5 Ki 5 IC50 4 EC50
  • Mu-type opioid receptor
  • US10231963, Table B.23
  • US10736890, Compound TABLE B.23
  • US10752592, Compound TABLE B.5
  • US9133125, Table B, Compound 5
  • US9656961, Example 00140
5 Ki 5 IC50 4 EC50
  • Mu-type opioid receptor
  • US10287250, Compound 1
  • US10736890, Compound TABLE C.1
  • US10752592, Compound TABLE D.1
  • US9133125, Table D, Compound 1
  • US9656961, Example 00165
14 IC50
  • Anandamide amidohydrolase
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6
  • Cytochrome P450 3A
  • Cytochrome P450 3A5 (CYP3A5)
  • LDL-associated phospholipase A2
  • Monoacylglycerol lipase ABHD6
  • Monoglyceride Lipase (MGL)
  • Monoglyceride lipase
  • US9133148, 9aq
8 Ki 6 IC50
  • 5'-nucleotidase
  • Ecto-5'-nucleotidase (e5'NT)
  • P2X purinoceptor 2
  • P2X purinoceptor 3
  • Phospholipase C, gamma 1
  • Phospholipase C-beta-3
  • tRNA synthetase (GlyRS)
  • ADP, alpha beta-me
  • AMPCPP
  • [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)methyl]phosphonic acid
  • alpha, beta-methyleneadenosine 5 -diphosphate
  • cid_92199
12 IC50 2 EC50
  • Dihydrofolate Reductase (DHFR)
  • Dihydrofolate reductase
  • Dihydrofolate reductase (DHFR)
  • Thymidylate Synthase (TS)
  • Thymidylate synthase
  • (2S)-2-{[4-({2,4-diamino-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl}sulfanyl)phenyl]formamido}pentanedioic acid
  • N-{4-[(2,4-diamino-5-methyl-7H-pyrrolo[2,3-d]-pyrimidin-6-yl)sulfanyl]benzoyl}-L-glutamic acid
  • Pyrrolo[2, 3-d]pyrimidine analogue, 1a
3 Ki 10 IC50 1 EC50
  • Alpha-mannosidase 2C1
  • Lactase-glycosylceramidase
  • Lysosomal acid glucosylceramidase
  • Lysosomal alpha-glucosidase
  • Maltase-glucoamylase
  • Mannosidase 2 alpha 1
  • Mannosidase 2, alpha B1
  • Trehalase
  • alpha-Glucosidase (α-Glucosidase)
  • alpha-Glucosidase (alpha-Glu)
  • alpha-glucosidase (Gaa)
  • (2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine-3,4,5-triol
  • CHEMBL75971
  • N-Methyl-DNJ
  • US9181184, 2
10 Ki 4 IC50
  • Beta-hexosaminidase subunit alpha (HexA)
  • Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS)
  • Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Mutant KICB1
  • Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Mutant SP21
  • 6-ethyl-5-(4-methylphenyl)pyrimidine-2,4-diamine
  • CHEMBL21778
  • P17
14 Ki
  • Coagulation factor III/Factor VIIa (fVIIa)
  • Coagulation factor IX
  • Coagulation factor VII
  • Coagulation factor X
  • Coagulation factor XI
  • Coagulation factor XII
  • Kallikrein 1
  • Plasma kallikrein
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Urokinase-type plasminogen activator/surface receptor
  • Vitamin K-dependent protein C
  • US9174974, Example 19
2 Ki 12 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Cytochrome P450 1A
  • Cytochrome P450 2C19
  • Cytochrome P450 2C9
  • Cytochrome P450 2D6 (2D6)
  • Cytochrome P450 2E1
  • Cytochrome P450 3A
  • Monoamine Oxidase Type B (MAO-B)
  • Monoamine oxidase
  • 7-(3-chlorobenzyloxy)-4-(methylamino)methyl-coumarin, 2
  • 7-[(3-chlorophenyl)methoxy]-4-[(methylamino)methyl]-2H-chromen-2-one
  • C18
  • CHEMBL593763
10 IC50 4 EC50
  • ATP-binding cassette sub-family G member 2
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Arachidonate 5-lipoxygenase
  • Axin-1/Glycogen synthase kinase-3 beta
  • Baculoviral IAP repeat-containing protein 2/Estrogen receptor
  • Estradiol receptor beta (ERβ)
  • Estrogen receptor
  • Voltage-dependent T-type calcium channel subunit alpha-1H
  • Voltage-gated T-type calcium channel
  • cGMP-specific 3',5'-cyclic phosphodiesterase
  • (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H-1-benzopyran-4-one
  • 8-prenylnaringenin (8-PN)
  • AIDS095901
  • CHEMBL376915
  • YS04
  • cid_509245
13 IC50 1 EC50
  • IDH1 R132C
  • IDH1 R132H
  • Isocitrate dehydrogenase 1 mutant (R132G)
  • Isocitrate dehydrogenase 2 (IDH2)
  • Isocitrate dehydrogenase 2 mutant (R140Q)
  • Isocitrate dehydrogenase 2 mutant (R172S)
  • Isocitrate dehydrogenase [NADP] cytoplasmic
  • GSK321
14 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 34
  • US9556187, Example 210
2 IC50 3 Kd 9 EC50
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
  • Alpha-crystallin B chain
  • GluN1/GluN2B NMDA receptor
  • HMG-CoA reductase
  • ITGAV/ITGB3
  • NR1/NR2A
  • Niemann-Pick C1-like protein 1
  • Nuclear receptor ROR-gamma (RORC)
  • OSBP-related protein 4 (ORP4L)
  • OSBP-related protein 4 (ORP4S)
  • Oxysterols receptor LXR-alpha
  • Sterol regulatory element-binding protein 2
  • (1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol
  • 25-Hydroxycholesterol (25OH)
  • 25-hydroxycholesterol
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 12
  • US10709712, Example 12
  • US9242969, 12
  • US9694016, 12
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 15
  • US10709712, Example 15
  • US9242969, 15
  • US9694016, 15
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 16
  • US10709712, Example 16
  • US9242969, 16
  • US9694016, 16
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 17
  • US10709712, Example 17
  • US9242969, 17
  • US9694016, 17
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 18
  • US10709712, Example 18
  • US9242969, 18
  • US9694016, 18
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 20
  • US10709712, Example 20
  • US9242969, 20
  • US9694016, 20
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 21
  • US10709712, Example 21
  • US9242969, 21
  • US9694016, 21
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 22
  • US10709712, Example 22
  • US9242969, 22
  • US9694016, 22
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 23
  • US10709712, Example 23
  • US9242969, 23
  • US9694016, 23
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 24
  • US10709712, Example 24
  • US9242969, 24
  • US9694016, 24
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 25
  • US10709712, Example 25
  • US9242969, 25
  • US9694016, 25
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 26
  • US10709712, Example 26
  • US9242969, 26
  • US9694016, 26
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 29
  • US10709712, Example 29
  • US9242969, 29
  • US9694016, 29
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 30
  • US10709712, Example 30
  • US9242969, 30
  • US9694016, 30
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 32
  • US10709712, Example 32
  • US9242969, 32
  • US9694016, 32
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 33
  • US10709712, Example 33
  • US9242969, 33
  • US9694016, 33
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 35
  • US10709712, Example 35
  • US9242969, 35
  • US9694016, 35
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 36
  • US10709712, Example 36
  • US9242969, 36
  • US9694016, 36
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 37
  • US10709712, Example 37
  • US9242969, 37
  • US9694016, 37
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 39
  • US10709712, Example 39
  • US9242969, 39
  • US9694016, 39
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 46
  • US10709712, Example 46
  • US9242969, 46
  • US9694016, 46
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 47
  • US10709712, Example 47
  • US9242969, 47
  • US9694016, 47
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 48
  • US10709712, Example 48
  • US9242969, 48
  • US9694016, 48
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 50
  • US10709712, Example 50
  • US9242969, 50
  • US9694016, 50
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 51
  • US10709712, Example 51
  • US9242969, 51
  • US9694016, 51
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 52
  • US10709712, Example 52
  • US9242969, 52
  • US9694016, 52
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 53
  • US10709712, Example 53
  • US9242969, 53
  • US9694016, 53
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 54
  • US10709712, Example 54
  • US9242969, 54
  • US9694016, 54
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 56
  • US10709712, Example 56
  • US9242969, 56
  • US9694016, 56
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 57
  • US10709712, Example 57
  • US9242969, 57
  • US9694016, 57
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 58
  • US10709712, Example 58
  • US9242969, 58
  • US9694016, 58
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 59
  • US10709712, Example 59
  • US9242969, 59
  • US9694016, 59
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 60
  • US10709712, Example 60
  • US9242969, 60
  • US9694016, 60
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 61
  • US10709712, Example 61
  • US9242969, 61
  • US9694016, 61
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 65
  • US10709712, Example 65
  • US9242969, 65
  • US9694016, 65
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 66
  • US10709712, Example 66
  • US9242969, 66
  • US9694016, 66
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 67
  • US10709712, Example 67
  • US9242969, 67
  • US9694016, 67
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 68
  • US10709712, Example 68
  • US9242969, 68
  • US9694016, 68
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 69
  • US10709712, Example 69
  • US9242969, 69
  • US9694016, 69
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 70
  • US10709712, Example 70
  • US9242969, 70
  • US9694016, 70
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 71
  • US10709712, Example 71
  • US9242969, 71
  • US9694016, 71
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 72
  • US10709712, Example 72
  • US9242969, 72
  • US9694016, 72
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 73
  • US10709712, Example 73
  • US9242969, 73
  • US9694016, 73
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 75
  • US10709712, Example 75
  • US9242969, 75
  • US9694016, 75
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 76
  • US10709712, Example 76
  • US9242969, 76
  • US9694016, 76
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 77
  • US10709712, Example 77
  • US9242969, 77
  • US9694016, 77
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 78
  • US10709712, Example 78
  • US9242969, 78
  • US9694016, 78
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 79
  • US10709712, Example 79
  • US9242969, 79
  • US9694016, 79
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 80
  • US10709712, Example 80
  • US9242969, 80
  • US9694016, 80
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 81
  • US10709712, Example 81
  • US9242969, 81
  • US9694016, 81
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 82
  • US10709712, Example 82
  • US9242969, 82
  • US9694016, 82
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 83
  • US10709712, Example 83
  • US9242969, 83
  • US9694016, 83
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 84
  • US10709712, Example 84
  • US9242969, 84
  • US9694016, 84
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 85
  • US10709712, Example 85
  • US9242969, 85
  • US9694016, 85
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 86
  • US10709712, Example 86
  • US9242969, 86
  • US9694016, 86
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 87
  • US10709712, Example 87
  • US9242969, 87
  • US9694016, 87
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 93
  • US10709712, Example 93
  • US9242969, 93
  • US9694016, 93
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 94
  • US10709712, Example 94
  • US9242969, 94
  • US9694016, 94
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 95
  • US10709712, Example 95
  • US9242969, 95
  • US9694016, 95
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 96
  • US10709712, Example 96
  • US9242969, 96
  • US9694016, 96
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 97
  • US10709712, Example 97
  • US9242969, 97
  • US9694016, 97
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 98
  • US10709712, Example 98
  • US9242969, 98
  • US9694016, 98
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 99
  • US10709712, Example 99
  • US9242969, 99
  • US9694016, 99
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 100
  • US10709712, Example 100
  • US9242969, 100
  • US9694016, 100
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 101
  • US10709712, Example 101
  • US9242969, 101
  • US9694016, 101
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 102
  • US10709712, Example 102
  • US9242969, 102
  • US9694016, 102
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 103
  • US10709712, Example 103
  • US9242969, 103
  • US9694016, 103
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 104
  • US10709712, Example 104
  • US9242969, 104
  • US9694016, 104
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 106
  • US10709712, Example 106
  • US9242969, 106
  • US9694016, 106
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 107
  • US10709712, Example 107
  • US9242969, 107
  • US9694016, 107
14 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 108
  • US10709712, Example 108
  • US9242969, 108
  • US9694016, 108
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