Search by Compound Name

Compound Name:

Compounds Sorted by Binding Data per Compound

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55
56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81
82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105
106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124
125 127 128 129 130 132 133 134 135 136 137 138 139 140 141 143 144 145 146
147 148 149 150 151 153 154 155 156 159 160 161 163 164 165 168 170 171 173
174 176 178 179 183 184 186 188 189 190 191 192 193 196 198 199 200 203 204
205 206 207 208 209 210 216 220 224 226 227 229 232 237 238 241 243 248 252
253 259 261 270 274 276 277 285 291 303 304 313 318 323 325 328 333 335 337
339 341 353 360 361 365 389 393 398 401 413 433 442 444 445 446 447 448 451
453 454 455 457 458 460 463 465 467 473 477 478 482 484 499 504 505 506 517
521 525 543 549 551 554 591 606 663 691 708 796 804 821 825 833 842 847 854
855 861 873 879 883 887 913 914 925 926 938 947 1010 1027 1050 1052 1081 1082
1099 1115 1130 1133 1206 1262 1543 1639 1903 2029
Compounds Sorted Alphabetically
Compound Name (alphabetical)
Enz. Inhib. Data
ITC Data
Binding Targets
Alternate Compound Names
18 IC50
  • Acetylcholinesterase
  • Cholinesterases
  • (3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-heptylcarbamate
  • CHEMBL433041
  • Eptastigmine
  • Heptylphysostigmine
18 Ki
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
  • US8691753, 61
  • US8691753, 72
18 Ki
  • 72 kDa type IV collagenase
  • Collagenase 3
  • Interstitial collagenase
  • Matrix metalloproteinase 10
  • Matrix metalloproteinase 14
  • Matrix metalloproteinase-12 (MMP12)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • Neutrophil collagenase
  • Stromelysin-1
  • US8691753, 95
  • US8691753, 96
3 Ki 15 IC50
  • Cathepsin B
  • Cathepsin F
  • Cathepsin K
  • Cathepsin L2
  • Cathepsin S
  • Chymase
  • Elastase 1
  • HCV NS3-NS4A Serine Proteinase
  • Leukocyte elastase
  • Nonstructural protein NS3-4A
  • Plasminogen
  • Procathepsin L
  • Replicase polyprotein 1ab
  • (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide
  • 3-{[(1R,2S,5S)-3-[(2S)-2-[(tert-butylcarbamoyl)amino]-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-yl]formamido}-4-cyclobutyl-2-oxobutanamide
  • BOCEPREVIR
  • SCH 503034
18 IC50
  • High affinity nerve growth factor receptor
  • JAK2 (aa 808-1132)
  • Tyrosine-protein kinase JAK2
  • US10251889, Example 51
  • US10758542, Example 51
  • US8791123, 50
  • US9782415, Example 51
  • US9796724, Example 51
18 Ki
  • Coagulation factor X
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Urokinase-type plasminogen activator
  • APC-10818
  • {amino[6-fluoro-2-(2-hydroxy-3-phenylphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium
18 Ki
  • Coagulation factor X
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Urokinase-type plasminogen activator
  • 6-fluoro-2-(2-hydroxy-3-{[(1S,2S)-2-methylcyclohexyl]oxy}phenyl)-1H-indole-5-carboximidamide
  • APC-11092
18 Ki
  • Coagulation factor X
  • Plasminogen
  • Prothrombin
  • Tissue-type plasminogen activator
  • Trypsin
  • Urokinase-type plasminogen activator
  • 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate
  • APC-10972
5 Ki 5 IC50 4 Kd 3 EC50 0 Other
  • Beta-secretase 1
  • Nck adaptor protein 1
  • Neutrophil cytosol factor 1
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase I218V
  • Nitric oxide synthase, inducible
  • Serotonin (5-HT) receptor
  • Serotonin 2 (5-HT2) receptor
  • Trypsin
  • Tryptase
  • Tyrosine-protein kinase HCK
  • Tyrosine-protein kinase TEC
  • 2-Aminoquinoline 1
  • 2-aminoquinoline
  • CHEMBL61236
  • Fragment 19
  • Quinolin-2-amine
  • fragment 2 (J. med. chem.,50,1116)
  • quinolin-2-amine
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 1
  • US8969352, 1
  • US9611277, Example 1
  • US9845333, 1
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 3
  • US8969352, 3
  • US9611277, Example 3
  • US9845333, 3
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 8
  • US8969352, 8
  • US9611277, Example 8
  • US9845333, 8
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 10
  • US8969352, 10
  • US9611277, Example 10
  • US9845333, 10
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 13
  • US8969352, 13
  • US9611277, Example 13
  • US9845333, 13
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 17
  • US8969352, 17
  • US9611277, Example 17
  • US9845333, 17
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 29
  • US8969352, 29
  • US9611277, Example 29
  • US9845333, 29
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 30
  • US8969352, 30
  • US9611277, Example 30
  • US9845333, 30
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 33
  • US8969352, 33
  • US9611277, Example 33
  • US9845333, 33
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 34
  • US8969352, 34
  • US9611277, Example 34
  • US9845333, 34
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 37
  • US8969352, 37
  • US9611277, Example 37
  • US9845333, 37
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 38
  • US8969352, 38
  • US9611277, Example 38
  • US9845333, 38
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 39
  • US8969352, 39
  • US9611277, Example 39
  • US9845333, 39
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 40
  • US8969352, 40
  • US9611277, Example 40
  • US9845333, 40
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 42
  • US8969352, 42
  • US9611277, Example 42
  • US9845333, 42
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 44
  • US8969352, 44
  • US9611277, Example 44
  • US9845333, 44
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 45
  • US8969352, 45
  • US9611277, Example 45
  • US9845333, 45
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 47
  • US8969352, 47
  • US9611277, Example 47
  • US9845333, 47
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 48
  • US8969352, 48
  • US9611277, Example 48
  • US9845333, 48
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 49
  • US8969352, 49
  • US9611277, Example 49
  • US9845333, 49
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 50
  • US8969352, 50
  • US9611277, Example 50
  • US9845333, 50
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 53
  • US8969352, 53
  • US9611277, Example 53
  • US9845333, 53
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 55
  • US8969352, 55
  • US9611277, Example 55
  • US9845333, 55
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 56
  • US8969352, 56
  • US9611277, Example 56
  • US9845333, 56
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 57
  • US8969352, 57
  • US9611277, Example 57
  • US9845333, 57
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 58
  • US8969352, 58
  • US9611277, Example 58
  • US9845333, 58
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • Orexin receptor type 2 (OX2)
  • US10183953, Example 59
  • US8969352, 59
  • US9611277, Example 59
  • US9845333, 59
13 Ki 2 IC50 1 Kd 1 Koff 1 Kon
  • HIV-1 Protease
  • HIV-1 protease
  • Human immunodeficiency virus type 1 protease
  • (4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis({[4-(hydroxymethyl)phenyl]methyl})-1,3-diazepan-2-one
  • DMP323
8 IC50 6 Kd
0 ΔG°
  • CDK4/CDK1
  • Cyclin-dependent kinase 2
  • Cyclin-dependent protein kinase 2 (CDK2 A144G)
  • Cyclin-dependent protein kinase 2 (CDK2 C118I)
  • Cyclin-dependent protein kinase 2 (CDK2 F80M)
  • Cyclin-dependent protein kinase 2 (CDK2 F80T)
  • Cyclin-dependent protein kinase 2 (CDK2 WT)
  • Cyclin-dependent protein kinase 2 variant (CDK2 A144C)
  • Cyclin-dependent protein kinase 2 variant (CDK2 C118L)
  • Cyclin-dependent protein kinase 2 variant (CDK2 C118L/A144C)
  • K03861 (1)
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • US9062078, 205
  • US9475819, 205
  • US9637496, 230
  • US9695183, 205
  • US9695183, 230
18 Ki
  • Orexin receptor type 1
  • Orexin receptor type 1 (OX1)
  • Orexin receptor type 2
  • US9062078, 207
  • US9475819, 207
  • US9637496, 229
  • US9695183, 207
  • US9695183, 229
18 IC50
  • BDNF/NT-3 growth factors receptor
  • High affinity nerve growth factor receptor
  • Macrophage colony-stimulating factor 1 receptor (CSF1R)
  • US10166239, Ex. 3-28
  • US9067914, Ex. 3-17
  • US9067914, Ex. 3-28
4 Ki 10 IC50 1 Kd 2 EC50
0 ΔG°
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA)
  • Bile Salt Export Pump, BSEP
  • Bile salt export pump (BSEP)
  • HMG-CoA reductase
  • Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
  • (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
  • CHEMBL1496
  • Ros
  • Rosuvastatin
  • US9102656, Rosuvastatin
  • ZD4522
9 Ki 8 IC50 1 EC50
  • 1,3-beta-glucan synthase component GLS2
  • Androgen Receptor
  • Androgen receptor
  • Androgen receptor/Baculoviral IAP repeat-containing protein 2
  • (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorobenzene)sulfonyl]-2-hydroxy-2-methylpropanamide
  • (R)-Bicalutamide
  • CHEMBL63560
  • US10806720, Compound R-Bicalutamide
18 IC50
  • Dihydrofolate Reductase (DHFR)
  • Dihydrofolate reductase
  • Dihydrofolate reductase (DHFR)
  • Thymidylate Synthase (TS)
  • Thymidylate synthase
  • Thymidylate synthase (EC 2.1.1.45) (TS) (TSase)
  • (2S)-2-{[4-({2-amino-6-methyl-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}sulfanyl)phenyl]formamido}pentanedioic acid
  • CHEMBL225180
  • Pyrrolo[2,3-d]pyrimidine analogue, 1
4 Ki 3 IC50 2 Kd
0 ΔG°
  • Aminoacyl-tRNA synthetase
  • Anthrax Lethal Factor (LF)
  • Bile salt export pump
  • Human immunodeficiency virus type 1 REV
  • Phosphatidylcholine specific phospholipase C, PC-PLC
  • Phosphatidylcholine-retinol O-acyltransferase
  • Phosphoinositide specific phospholipase C, PI-PLC
  • RNA(23-mer)
  • Vascular endothelial growth factor receptor 2
  • (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol
  • KDR Kinase Inhibitor, 3
  • Neomycin
  • Neomycin B
16 IC50 2 Kd
  • Lysine-specific demethylase 4C
  • Lysine-specific demethylase 5A
  • Lysine-specific demethylase 5A (KDM5A(aa 1-1090)-Flag)
  • Lysine-specific demethylase 5A (KDM5A(aa 1-588)ΔAP)
  • Lysine-specific demethylase 5A (KDM5A(aa 1-739)ΔAP(2C-2S))
  • Lysine-specific demethylase 5B
  • Lysine-specific demethylase 5B (KDM5B(aa 1-604)ΔAP)
  • Lysine-specific demethylase 5B (KDM5B(aa 1-755)ΔAP)
  • Lysine-specific demethylase 5C
  • Lysine-specific demethylase 5C (KDM5C(aa 1-789)ΔAP)
  • Lysine-specific demethylase 5D (KDM5D(aa 1-760)ΔAP)
  • 3-((1-methyl-1Hpyrrolo[2,3-b]pyridin-3-yl)amino)isonicotinic acid (N12)
  • US10040779, Example 52
  • US10336727, Example 52
  • US9617242, Example 52
18 IC50
  • Non-receptor tyrosine-protein kinase TYK2
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase JAK3
  • US9216999, 26
  • US9556187, Example 84
6 Ki 2 IC50 5 EC50
0 ΔG°
  • Cholecystokinin
  • Heat Shock 70kDa Protein 1
  • P2X purinoceptor 2
  • P2X purinoceptor 3
  • P2Y purinoceptor 1
  • Purinergic receptor P2Y1
  • Purinergic receptor P2Y11
  • Purinergic receptor P2Y2
  • Thymidine Kinase (TK.dT)
  • adrenergic Alpha2
  • tRNA synthetase (GlyRS)
  • ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
  • ATP
  • Brimonidine ATP
  • CHEMBL14249
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 7
  • US10709712, Example 7
  • US9242969, 7
  • US9694016, 7
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 10
  • US10709712, Example 10
  • US9242969, 10
  • US9694016, 10
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 11
  • US10709712, Example 11
  • US9242969, 11
  • US9694016, 11
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 13
  • US10709712, Example 13
  • US9242969, 13
  • US9694016, 13
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 14
  • US10709712, Example 14
  • US9242969, 14
  • US9694016, 14
18 IC50
  • B-RAF V600E
  • C-RAF
  • RAF proto-oncogene serine/threonine-protein kinase
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 40
  • US10709712, Example 40
  • US9242969, 40
  • US9694016, 40
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 43
  • US10709712, Example 42
  • US9242969, 42
  • US9694016, 42
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 44
  • US10709712, Example 44
  • US9242969, 44
  • US9694016, 44
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 45
  • US10709712, Example 45
  • US9242969, 45
  • US9694016, 45
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 63
  • US10709712, Example 63
  • US9242969, 63
  • US9694016, 63
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 118
  • US10709712, Example 118
  • US9242969, 118
  • US9694016, 118
18 IC50
  • B-RAF V600E
  • C-RAF
  • C-Raf TR (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase
  • RAF proto-oncogene serine/threonine-protein kinase (aa 1-324)
  • RAF proto-oncogene serine/threonine-protein kinase (truncated)(325-648)
  • Serine/threonine-protein kinase B-raf
  • US10245267, Example 196
  • US10709712, Example 196
  • US9242969, 196
  • US9694016, 196
12 IC50 5 Kd 1 EC50
  • Heat Shock Protein 90 (Hsp90)
  • Heat shock protein 75 kDa, mitochondrial
  • Heat shock protein 90 beta
  • Heat shock protein HSP 90
  • Heat shock protein HSP 90-alpha
  • Heat shock protein HSP 90-beta
  • (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
  • BODIPY-labeled Geldanamycin
  • CHEMBL278315
  • GM-BODIPY
  • Geldanamycin
  • geldanomycin
18 IC50
  • Cereblon/Histone deacetylase 6
  • Histone deacetylase 1
  • Histone deacetylase 10
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Histone deacetylase 9
  • US9265734, RGFA8
  • US9796664, Compound RGFA8
2 Ki 16 IC50
  • Cereblon/Histone deacetylase 1
  • Histone deacetylase 1
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • Leukotriene A4 hydrolase
  • US9265734, R01
  • US9796664, Compound R01
7 Ki 6 IC50 5 EC50
  • Delta-type opioid receptor
  • Mu-type opioid receptor
  • Neurokinin 1 receptor
  • Bifunctional Peptide Ligand, 5 (TY005)
  • CHEMBL389652
  • H-Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-O-3,5-Bzl(CF3)2
  • [3,5-bis(trifluoromethyl)phenyl]methyl (2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanamido]-4-(methylsulfanyl)butanoyl]pyrrolidin-2-yl]formamido}-4-methylpentanamido]-3-(1H-indol-3-yl)propanoate
9 Kd
0 ΔG°
  • Caseinolytic protein C1 (ClpC1 NTD E89A)
  • Caseinolytic protein C1 (ClpC1 NTD E89Q)
  • Caseinolytic protein C1 (ClpC1 NTD F2A)
  • Caseinolytic protein C1 (ClpC1 NTD F2Y)
  • Caseinolytic protein C1 (ClpC1 NTD F80A)
  • Caseinolytic protein C1 (ClpC1 NTD F80Y)
  • Caseinolytic protein C1 (ClpC1 NTD)
  • Caseinolytic protein C1 (ClpC1 NTD-D1)
  • Caseinolytic protein C1 (ClpC1)
  • Cyclomarin A1 (CymA1)
4 Ki 14 IC50
  • Bile salt export pump
  • Cytochrome P450 3A
  • Gamma-aminobutyric acid receptor subunit alpha-1
  • P-glycoprotein (P-gp)
  • P-glycoprotein 1
  • P-glycoprotein 1 and 3 (MDR1a/MDR1b)
  • Peripheral-Type Benzodiazepine Receptor
  • Solute carrier family 22 member 1
  • Uridine-5'-diphosphoglucuronosyltransferase 1A1
  • Uridine-5'-diphosphoglucuronosyltransferase 1A6
  • Uridine-5'-diphosphoglucuronosyltransferase 2B10
  • Uridine-5'-diphosphoglucuronosyltransferase 2B7
  • 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
  • 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
  • CHEMBL655
  • Dormicum
  • Midazolam
  • Ro 21-3981
13 Ki 1 Kd 4 EC50
  • Delta-type opioid receptor
  • Kappa-type opioid receptor
  • Mu-type opioid receptor
  • Nociceptin receptor
  • Nociceptin/Orphanin FQ, NOP receptor
  • Nociceptin/mu opioid receptor
  • Opioid receptors; mu & delta
  • (2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-{2-[(2S,3R)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-phenylpropanamido]acetamido}acetamido)-3-phenylpropanamido]-3-hydroxybutanamido]acetamido}propanamido]-5-carbamimidamidopentanamido]hexanamido]-3-hydroxypropanamido]propanamido]-5-carbamimidamidopentanamido]hexanamido]-4-methylpentanamido]propanamido]butanediamido]-4-carbamoylbutanoic acid
  • N/OFQ
  • OFQ 1-17
  • OFQ/N
  • Orphanin FQ
  • [125I]-nociceptin
  • nociceptin
18 Ki
  • Nitric Oxide Synthase, brain
  • Nitric Oxide Synthase, brain Mutant (D597N)
  • Nitric Oxide Synthase, endothelial
  • Nitric Oxide Synthase, endothelial Mutant (N368D)
  • Nitric Oxide Synthase, inducible
  • Nitric-oxide synthase, brain
  • 3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-nitroguanidine
  • CHEMBL227937
  • JMC522060 Compound 2
  • N omega-Nitro-L-Arginine-Containing Dipeptide, 1
17 Ki 1 Kd
  • Alpha-1A adrenergic receptor
  • HRH3
  • Histamine H1 receptor
  • Histamine H2 receptor
  • Histamine H3 receptor
  • Histamine H4 receptor
  • 1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea
  • Burimamide
  • CHEMBL12160
18 IC50
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase JAK2
  • US10106559, Example 22
  • US10435415, Example 22
  • US9334290, 20
  • US9850258, Example 52
18 IC50
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase JAK2
  • US10106559, Example 33
  • US10435415, Example 33
  • US9334290, 32
  • US9850258, Example 33
18 IC50
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase JAK2
  • US10106559, Example 45
  • US10435415, Example 60
  • US9334290, 44
  • US9334290, 45
  • US9850258, Example 45
18 IC50
  • Tyrosine-protein kinase BTK
  • Tyrosine-protein kinase JAK2
  • US10106559, Example 56
  • US10435415, Example 59
  • US9334290, 55
  • US9334290, 56
  • US9850258, Example 56
18 IC50
  • 72 kDa type IV collagenase
  • A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
  • Collagenase 3
  • Disintegrin and metalloproteinase domain-containing protein 17
  • Interstitial collagenase
  • Matrix metalloproteinase-14 (MMP14)
  • Matrix metalloproteinase-7 (MMP7)
  • Matrix metalloproteinase-9
  • (3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
  • CHEMBL207729
  • TMI-1
18 Ki
  • Coagulation factor IX
  • Coagulation factor XI
  • Plasma kallikrein
  • BDBM241596
  • US9409908, 153
  • US9409908, 159
  • US9409908, 218
  • US9409908, 225
  • US9951071, Example 225
2 Ki 14 IC50 2 EC50
  • Bile salt export pump
  • Canalicular multispecific organic anion transporter 1
  • Canalicular multispecific organic anion transporter 2
  • GABA-B receptor 1/2
  • Gamma-aminobutyric acid type B receptor subunit 1
  • Multidrug resistance-associated protein 4
  • gamma-Aminobutyric Acid Type B Receptor
  • 4-amino-3-(4-chlorophenyl)butanoic acid
  • Baclofen
  • Baclophen
  • CHEMBL701
  • Gabalon
  • Lioresal
9 Ki 9 IC50
  • Cannabinoid receptor 1
  • Cannabinoid receptor 2
  • US9422235, 4
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 1
  • US10836768, Cpd no 1
  • US9422299, 1
  • US9987274, Compound 1
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 2
  • US10836768, Cpd no 2
  • US9422299, 2
  • US9987274, Compound 2
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 4
  • US10836768, Cpd no 4
  • US9422299, 4
  • US9987274, Compound 4
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 6
  • US10836768, Cpd no 6
  • US9422299, 6
  • US9987274, Compound 6
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 7
  • US10836768, Cpd no 7
  • US9422299, 7
  • US9987274, Compound 7
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 8
  • US10836768, Cpd no 8
  • US9422299, 8
  • US9987274, Compound 8
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 9
  • US10836768, Cpd no 9
  • US9422299, 9
  • US9987274, Compound 9
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 10
  • US10836768, Cpd no 10
  • US9422299, 10
  • US9987274, Compound 10
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 13
  • US10836768, Cpd no 13
  • US9422299, 13
  • US9987274, Compound 13
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 15
  • US10836768, Cpd no 15
  • US9422299, 15
  • US9987274, Compound 15
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 16
  • US10836768, Cpd no 16
  • US9422299, 16
  • US9987274, Compound 16
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 17
  • US10836768, Cpd no 17
  • US9422299, 17
  • US9987274, Compound 17
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 18
  • US10836768, Cpd no 18
  • US9422299, 18
  • US9987274, Compound 18
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 21
  • US10836768, Cpd no 21
  • US9422299, 21
  • US9987274, Compound 21
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 22
  • US10836768, Cpd no 22
  • US9422299, 22
  • US9987274, Compound 22
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 24
  • US10836768, Cpd no 24
  • US9422299, 24
  • US9987274, Compound 24
12 Ki 6 IC50
  • Melanin-concentrating hormone receptor 2/HERG
  • Neurokinin 1 receptor
  • Neurokinin 2 receptor
  • Neurokinin 3 receptor
  • Neuromedin-K receptor
  • Neuromedin-K receptor (NK-3 receptor)
  • Potassium voltage-gated channel subfamily H member 2
  • hnk-3
  • US10030025, Compound 30
  • US10836768, Cpd no 30
  • US9422299, 30
  • US9987274, Compound 30
18 EC50
  • Serine protease NS3/RNA-directed RNA polymerase NS5B (NS3-NS5B)
  • Serine protease NS5A (L28T)
  • Serine protease NS5A (L31F)
  • Serine protease NS5A (L31M)
  • Serine protease NS5A (L31V)
  • Serine protease NS5A (R30H)
  • Serine protease NS5A (Y93C)
  • Serine protease NS5A (Y93H)
  • US9433609, 2
  • US9433609, 4
18 IC50
  • Coagulation factor XI
  • Plasma kallikrein
  • US10183932, Example 89
  • US9434690, 87
  • US9434690, 88
  • US9434690, 89
  • US9822102, Example 89
18 IC50
  • Coagulation factor XI
  • Plasma kallikrein
  • US10183932, Example 100
  • US9434690, 100
  • US9434690, 97
  • US9434690, 98
  • US9434690, 99
  • US9822102, Example 100
18 IC50
  • Coagulation factor XI
  • Plasma kallikrein
  • US10183932, Example 147
  • US9434690, 145
  • US9434690, 146
  • US9434690, 147
  • US9822102, Example 147
18 IC50
  • JAK1 (aa 837-1142)
  • Tyrosine-protein kinase JAK1
  • Tyrosine-protein kinase JAK2
  • Tyrosine-protein kinase Mer
  • Tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase receptor UFO
  • 4-{3-(Cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]azetidin-1-yl}-N- [4-fluoro-2- (trifluoromethyl) phenyl]piperidine-1- carboxamide
  • US10053465, 8
  • US10065963, Compound 8
  • US10125150, Example 8
  • US10336759, # 8
  • US10479803, Example 8
  • US10519163, Example 8
  • US10675284, Example 8
  • US9732097, Example 8
  • US9999619, Example 154
2 Ki 15 IC50 1 Kd
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • Carbon monoxide dehydrogenase (CODH)
  • Dual specificity mitogen-activated protein kinase kinase 1
  • Dual specificity phosphatase Cdc25B
  • Dual specificity protein phosphatase 1
  • Histone-lysine N-methyltransferase EHMT1
  • Human rhinovirus A protease
  • Indoleamine 2,3-dioxygenase
  • MKP-3
  • Monoamine oxidase B (MAO-B)
  • Papain
  • Protein G9a (G9a)
  • RAC-alpha serine/threonine-protein kinase
  • 1,4-Naphthoquinone
  • 1,4-Naphthoquinone (5a)
  • 1,4-dihydronaphthalene-1,4-dione
  • 1,4-naphtho-quinone, 3
  • CHEMBL55934
18 IC50
  • Fibroblast growth factor receptor 1
  • Fibroblast growth factor receptor 2
  • Fibroblast growth factor receptor 3
  • Fibroblast growth factor receptor 4
  • US10537571, Compound 100
  • US9434697, 100
  • US9730931, Compound 100
18 IC50
  • Cereblon/Histone deacetylase 6
  • Histone Deacetylase 4 (HDAC4) Mutant (H976Y)
  • Histone deacetylase 1
  • Histone deacetylase 2
  • Histone deacetylase 3
  • Histone deacetylase 4
  • Histone deacetylase 5
  • Histone deacetylase 7
  • Histone deacetylase 8
  • 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl]acetamide
  • 4-phenylimidazole, 17
  • CHEMBL407959
18 IC50
  • CDK2/CycE
  • CDK2/Cyclin A1
  • Cyclin-Dependent Kinase 2 (CDK2)
  • Cyclin-Dependent Kinase 4 (CDK4)
  • US9464092, AAA
  • US9464092, FFF
  • US9527857, FFF
6 Ki 12 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10112937, Example 77
  • US10150765, Example 77
  • US10703749, Example 77
  • US9464084, 77
6 Ki 12 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10112937, Example 105
  • US10150765, Example 107
  • US10703749, Example 105
  • US9464084, 105
6 Ki 12 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10112937, Example 252
  • US10150765, Example 252
  • US10703749, Example 253
  • US9464084, 252
6 Ki 12 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10112937, Example 274
  • US10150765, Example 280
  • US10703749, Example 274
  • US9464084, 274
6 Ki 12 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10112937, Example 278
  • US10150765, Example 281
  • US10703749, Example 278
  • US9464084, 278
6 Ki 12 IC50
  • P2X purinoceptor 7
  • P2X purinoceptor 7 (P2X7)
  • US10112937, Example 279
  • US10150765, Example 283
  • US10703749, Example 279
  • US9464084, 279
9 Ki 9 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine Specific Demethylase-1 (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10214477, Example 8
  • US9469597, 8
  • US9670136, 8 N1-((trans)-2-(6-(3-(trifluoromethyl)phenyl)pyridin-3-yl)cyclopropyl)cyclohexane-1,4-diamine
9 Ki 9 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine Specific Demethylase-1 (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10214477, Example 13
  • US9469597, 13
  • US9670136, 13 N-(4-(((trans)-2-(6-(3-(trifluoromethyl)phenyl)pyridin-3-yl)cyclopropyl)amino)cyclohexyl)acetamide
9 Ki 9 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine Specific Demethylase-1 (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10214477, Example 14
  • US9469597, 14
  • US9670136, 14 N-(4-(((trans)-2-(6-(3-(trifluoromethyl)phenyl)pyridin-3-yl)cyclopropyl)amino)cyclohexyl)methanesulfonamide
9 Ki 9 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine Specific Demethylase-1 (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10214477, Example 15
  • US9469597, 15
  • US9670136, 15 (R)-1-(4-(((trans)-2-phenylcyclopropyl)amino)cyclohexyl)pyrrolidin-3-amine trihydrochloride
9 Ki 9 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10329256, Example 6
  • US9487512, 6
  • US9944601, Example 6
9 Ki 9 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10329256, Example 7
  • US9487512, 7
  • US9944601, Example 7
9 Ki 9 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10329256, Example 8
  • US9487512, 8
  • US9944601, Example 8
9 Ki 9 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10329256, Example 9
  • US9487512, 9
  • US9944601, Example 9
18 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10053456, 1
  • US10414761, Example 1
  • US9487511, 1
  • US9718814, 1
  • US9920047, 1
18 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10053456, 3
  • US10414761, Example 3
  • US9487511, 3
  • US9718814, 3
  • US9920047, 3
18 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10053456, 4
  • US10414761, Example 4
  • US9487511, 4
  • US9718814, 4
  • US9920047, 4
18 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10053456, 5
  • US10414761, Example 5
  • US9487511, 5
  • US9718814, 5
  • US9920047, 5
18 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10053456, 6
  • US10414761, Example 6
  • US9487511, 6
  • US9718814, 6
  • US9920047, 6
18 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10053456, 7
  • US10414761, Example 7
  • US9487511, 7
  • US9718814, 7
  • US9920047, 7
18 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10053456, 8
  • US10414761, Example 8
  • US9487511, 8
  • US9718814, 8
  • US9920047, 8
18 IC50
  • Amine oxidase (flavin-containing) A
  • Amine oxidase [flavin-containing] B
  • GST-Lysine-specific histone demethylase 1A (LSD1)
  • Lysine-specific histone demethylase 1A
  • US10053456, 9
  • US10414761, Example 9
  • US9487511, 9
  • US9718814, 9
  • US9920047, 9
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