PMID

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Article Title

Organization

Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors.

Academia Sinica

Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation.

Chonnam National University

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.

Konkuk University

Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase.

Konkuk University

Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease.

Wichita State University

Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine.

University of Oxford

Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19.

Shionogi

In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease.

Shanghai Institute of Materia Medica

Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CL

Shanghai University of Traditional Chinese Medicine

Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.

The University of Arizona

Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2.

China Pharmaceutical University

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.

Shandong University

The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities.

Niddk

Novel Coronavirus Main Protease Di- and Tripeptide Inhibitors for Treating COVID-19.

Experimental Drug Development Centre

Bisubstrate Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 Nsp14 Methyltransferase.

University of Minnesota

Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (M

University of Colorado

Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir.

Australian National University

Discovery of highly potent SARS-CoV-2 M

Nanjing University of Chinese Medicine

The Natural Products Withaferin A and Withanone from the Medicinal Herb

Shiv Nadar University

A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir.

Experimental Drug Development Centre

Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir.

Texas A&M University

Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease.

Peking University

The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate.

Nankai University

Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.

The State University of New Jersey

Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities.

University of Naples "Federico Ii

Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination.

Eberhard Karls University T£Bingen

Novel Halomethylketone Azadipeptides for Treating COVID-19.

A*Star

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity.

University of Perugia

Target-Based Virtual Screening and LC/MS-Guided Isolation Procedure for Identifying Phloroglucinol-Terpenoid Inhibitors of SARS-CoV-2.

Kunming Institute of Botany

Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy.

Eberhard Karls University T£Bingen

Chemo- and Site-Selective Lysine Modification of Peptides and Proteins under Native Conditions Using the Water-Soluble Zolinium.

Chinese Academy of Sciences

Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.

University of Alberta Edmonton

Oral Nonpeptidic, Noncovalent Triazine Coronavirus Main Protease Inhibitors for Treating COVID-19.

Experimental Drug Development Centre

Tuaimenal A, a Meroterpene from the Irish Deep-Sea Soft Coral

University of South Florida

Aspulvins A-H, Aspulvinone Analogues with SARS-CoV-2 M

Yunnan University

Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteases.

Heidelberg University

A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals.

Texas A&M University

A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.

Texas A&M University

Discovery of 2-thiobenzimidazoles as noncovalent inhibitors of SARS-CoV-2 main protease.

New York University Abu Dhabi

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.

Kyushu University

Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease.

Bio-Techne (Tocris)

Chalcone-amide, a privileged backbone for the design and development of selective SARS-CoV/SARS-CoV-2 papain-like protease inhibitors.

Mazandaran University of Medical Sciences

Advanced approaches of developing targeted covalent drugs.

College of Pharmacy

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.

Shandong University

Anti-SARS-CoV-2 Activity of

Mahidol University

Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2.

University of California San Diego

Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors.

Jadavpur University

Discovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors.

Chinese Academy of Medical Science and Peking Union Medical College

Promising anti-SARS-CoV-2 drugs by effective dual targeting against the viral and host proteases.

Bristol University

Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors.

Australian National University

Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling.

University of Illinois At Chicago

Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.

University of Illinois At Chicago

Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors.

Tianjin University of Science and Technology

Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors.

Kansas State University

Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.

Korea Research Institute of Bioscience and Biotechnology

Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases.

The Chinese University of Hong Kong

Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors.

Academia Sinica

Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition.

Korea Research Institute of Bioscience and Biotechnology

SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii.

Korea Research Institute of Bioscience and Biotechnology

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death.

National Human Genome Research Institute

New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.

Kyoto Pharmaceutical University

Novel small-molecule inhibitors of transmissible gastroenteritis virus.

National Health Research Institute

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors.

Purdue University

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.

Wichita State University

A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408).

Wyeth Research

Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.

Boehringer Ingelheim Pharmaceuticals

Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.

Universita Di Pisa

Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.

Amgen

Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.

University of Alberta