13 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
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Article Title
Organization
Targeting the homologous recombination pathway by small molecule modulators.
Drexel University College of Medicine
Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.
National Center For Advancing Translational Sciences
Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen.
Abbvie
Novel Spirocyclic WRN Helicase Inhibitors for Treating Cancer.
Smith, Gambrell & Russell LLP
Discovery of novel WRN inhibitors for treating MSI-H colorectal cancers.
Korea Research Institute of Bioscience and Biotechnology
An update on small molecule compounds targeting synthetic lethality for cancer therapy.
Sichuan University
Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors.
Shanghai Institute of Materia Medica
Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening.
Sun Yat-sen University
Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
Korea University
Pharmaceutically active pyrazolo-pyridone modulators of DCN1/2-mediated cullin neddylation
University of Kentucky Research Foundation; Memorial Sloan-Kettering Cancer Center; St. Jude Children''s Research Hospital, Inc.