BDBM50058046 CHEMBL526::propofol

SMILES CC(C)c1cccc(C(C)C)c1O

InChI Key InChIKey=OLBCVFGFOZPWHH-UHFFFAOYSA-N

Data  2 KI  5 IC50  8 EC50

PDB links: 8 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50058046   

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Ataturk University

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataKi:  1.95E+4nMAssay Description:Inhibition of human erythrocyte CA2 esterase activity using 4-nitrophenyl acetate substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Ataturk University

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataKi:  9.89E+4nMAssay Description:Inhibition of human erythrocyte CA1 esterase activity using 4-nitrophenyl acetate substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Organon Research And Development Group

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataEC50:  4.10E+3nMAssay Description:GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...More data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Organon Research And Development Group

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataEC50:  5.00E+4nMAssay Description:GABA-mimetic action on Oocytes expressing human alpha-1-beta-3-gamma-2L GABA-A receptor subunits at >=100 uMMore data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataEC50:  1.12E+4nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibitory concentration against fatty acid amide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of rat FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
University Of Chicago Medical Center

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataEC50:  1.00E+4nMAssay Description:Direct activation of human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
University Of Chicago Medical Center

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataEC50:  2.00E+3nMAssay Description:Potentiation of GABA responses at human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Organon Research And Development Group

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataEC50:  5.40E+3nMAssay Description:Positive allosteric modulation of GABAA alpha1beta3gamma2L in HEK cell plasma membrane assessed as increase in [3H]muscimol binding measured after 10...More data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Organon Research And Development Group

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of [3H]azietomidate labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in ph...More data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Organon Research And Development Group

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of [3H]R-mTFD-MPAB labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction in pho...More data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Organon Research And Development Group

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of [3H]pTFD-di-iPr-BnOH labelling of GABAA alpha1beta3gamma2L (unknown origin) expressed in Xenopus laevis oocytes assessed as reduction i...More data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataEC50:  4.40E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
TargetGABA A receptor alpha-1/beta-1/gamma-2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50058046(CHEMBL526 | propofol)
Affinity DataEC50:  8.00E+3nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunitsMore data for this Ligand-Target Pair