BDBM50081174 CHEMBL3421968

SMILES COc1cc(ccc1Nc1nccc(n1)-c1cn(C)c2cnccc12)N1CCN(C)CC1

InChI Key InChIKey=ZYVXTMKTGDARKR-UHFFFAOYSA-N

Data  2 KI  25 IC50  3 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50081174   

LigandPNGBDBM50081174(CHEMBL3421968)
Affinity DataKi:  4.40nMAssay Description:Inhibition of human DYRK1A incubated for 90 mins in presence of ATP by Z-LYTE based FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50081174(CHEMBL3421968)
Affinity DataIC50:  153nMAssay Description:Inhibition of NanoLuc-fused human DYRK1A expressed in HEK293 cells using Nano-Glo as substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50081174(CHEMBL3421968)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
LigandPNGBDBM50081174(CHEMBL3421968)
Affinity DataIC50:  17nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50081174(CHEMBL3421968)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Escherichia coli using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by...More data for this Ligand-Target Pair
LigandPNGBDBM50081174(CHEMBL3421968)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50081174(CHEMBL3421968)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of Dyrk1A (unknown origin)More data for this Ligand-Target Pair