BDBM50081174 CHEMBL3421968

SMILES COc1cc(ccc1Nc1nccc(n1)-c1cn(C)c2cnccc12)N1CCN(C)CC1

InChI Key InChIKey=ZYVXTMKTGDARKR-UHFFFAOYSA-N

Data  2 KI  25 IC50  3 Kd

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50081174   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataKi:  4.40nMAssay Description:Inhibition of human DYRK1A incubated for 90 mins in presence of ATP by Z-LYTE based FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataKi:  11nMAssay Description:Inhibition of human DYRK1B incubated for 130 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant Dyrk1B (unknown origin) using FITC-Asp-His-Thr-Gly-Phe-Leu-Thr-Glu-Tyr-Val-Ala-Thr-Arg-NH2 as substrate after 60 minsMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  779nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged IGF-1R using fluorescence substrate after 80 mins by caliper off-chip incubation mobility shif...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  42nMAssay Description:Inhibition of human full length C-terminal c-Myc tagged Dyrk1B phosphorylation overexpressed in monkey COS1 cells after 5 hrs by ELISAMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  4.47E+3nMAssay Description:Inhibition of human recombinant full length C-terminal His6-tagged CDK2 expressed in baculovirus infected Sf21 insect cells using fluorescence substr...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  153nMAssay Description:Inhibition of NanoLuc-fused human DYRK1A expressed in HEK293 cells using Nano-Glo as substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  81nMAssay Description:Inhibition of NanoLuc-fused human DYRK1B expressed in HEK293T cells using Nano-Glo as substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric sc...More data for this Ligand-Target Pair

Target InfoMMDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetCasein kinase I isoform epsilon(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  568nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK3(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  403nMAssay Description:Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  17nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  17nMAssay Description:Inhibition of DYRK1B (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  764nMAssay Description:Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  6.25E+3nMAssay Description:Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  175nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells using myelin basic protein as substrate incubated for 110 mins in presence of ATP ...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Escherichia coli using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  8.30nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataKd:  2.60nMAssay Description:Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataKd:  7.40nMAssay Description:Binding affinity to human CLK1 assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human GSK-3beta assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Ach£

Curated by ChEMBL

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of Dyrk1A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))TBA

LigandBDBM50081174(CHEMBL3421968)Copy SMILESCopy InChI

Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of Dyrk2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI