BDBM18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US20230339856, Compound DNJ::US9181184, 1::dNM
SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
InChI Key InChIKey=LXBIFEVIBLOUGU-JGWLITMVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 108 hits for monomerid = 18351
Affinity DataKi: 1.80E+4nM IC50: 3.95E+4nMAssay Description:All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin
Curated by ChEMBL
Technische Universit£T Berlin
Curated by ChEMBL
Affinity DataKi: 7.90E+4nM ΔG°: -5.82kcal/mole IC50: 2.40E+5nMpH: 5.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+5nMpH: 7.0 T: 2°CAssay Description:The alpha-glucosidase inhibitory activity of test compounds was determined in a 96-well plate format. The reaction mixture containing enzyme and chro...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Human embryonic kidney (HEK) 293 cells were cultured in D-MEM medium. Transfections were performed by the calcium phosphate coprecipitation method. T...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Human embryonic kidney (HEK) 293 cells were cultured in D-MEM medium. Transfections were performed by the calcium phosphate coprecipitation method. T...More data for this Ligand-Target Pair
Affinity DataIC50: 2.78E+5nMpH: 7.0 T: 2°CAssay Description:α-glucosidase (25 μL, 0.2 U/mL), 25 μL of various concentrations of samples, and 175 μL of 50 mM sodium phosphate buffer (pH 7.0)...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian cytosolic beta-galactosidase was determined in bovine liverMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:Concentration that causes 50% inhibition of mammalian beta-galactosidase (lactase ) was determined in rat intestineMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-mannosidase (Golgi I) was determined in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-glucosidase (maltase) was determined in rat intestineMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian cellobiase beta-glucosidase was determined in rat intestineMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-mannosidase (lysosomal) was determined in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+4nMAssay Description:Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestineMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian epididymal beta-galactosidase was determined in rat epididymisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liverMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-mannosidase was determined in rat epididymisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+4nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestineMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-mannosidase (Golgi II) was determined in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian lysosomal beta-galactosidase was determined in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Tested for competitive inhibition of endoplasmic reticulum alpha-glucosidase II.More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of lysosomal Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of sucrase by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of yeast maltase alpha-glucosidase assessed as p-nitrophenol release by spectrophotometricallyMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of rat liver lysosome alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-testMore data for this Ligand-Target Pair
TargetOligo-1,6-glucosidase IMA1(Saccharomyces cerevisiae S288c (Baker's yeast))
Hokuriku University
Curated by ChEMBL
Hokuriku University
Curated by ChEMBL
Affinity DataIC50: 3.30E+5nMAssay Description:Inhibition of yeast alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-testMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of rat intestinal maltase assessed as D-glucose release after 30 mins by Glucose B-testMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Caldocellum saccharolyticum beta-glucosidase assessed as D-glucose release after 30 mins by Glucose B-testMore data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of alpha glucosidase from bacillus sterothermophilusMore data for this Ligand-Target Pair
TargetCytosolic beta-glucosidase(Homo sapiens (Human))
Toyama Medical And Pharmaceutical University
Curated by ChEMBL
Toyama Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibitory concentration against beta-glucosidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human GBA2More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Technische Universit£T Berlin
Curated by ChEMBL
Technische Universit£T Berlin
Curated by ChEMBL
Affinity DataIC50: 5.06E+5nMAssay Description:Displacement of 4-methylumbelliferyl from human GBA by fluorometryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.88E+4nMAssay Description:Displacement of 4-methylumbelliferyl from non-lysosomal GBA2 by fluorometryMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GCS by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of GBA2 by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glycogen glycogen de-branching enzyme by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of maltase by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of lactase by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of rat intestinal isomaltase assessed as production of p-nitrophenol at by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometryMore data for this Ligand-Target Pair