BDBM21398 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)::4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one::CHEMBL54::CHEMBL545608::Haloperidol::Haloperidol, 1
SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
InChI Key InChIKey=LNEPOXFFQSENCJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 170 hits for monomerid = 21398
Affinity DataIC50: >2.00E+3nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Siena
Curated by ChEMBL
University of Siena
Curated by ChEMBL
Affinity DataIC50: 26.8nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
Affinity DataIC50: 1.42E+5nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Siena
Curated by ChEMBL
University of Siena
Curated by ChEMBL
Affinity DataIC50: 28.2nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Siena
Curated by ChEMBL
University of Siena
Curated by ChEMBL
Affinity DataIC50: 30.2nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Siena
Curated by ChEMBL
University of Siena
Curated by ChEMBL
Affinity DataIC50: 30.2nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Compound was tested for anti-dopamine activity in vitro by its ability to displace [3H]spiperone from rat brain striatal preparations,More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:compound was tested for inhibition of 0.5 nM [3H]spiroperidol binding to dopamine receptor from rat striatal membrane.More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of [3H]dopamine binding to Dopamine receptor in calf caudate nuclei.More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of [3H]haloperidol binding to Dopamine receptor in calf caudate nuclei.More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:The compound was tested for inhibition of [3H]WB-4101 binding to alpha-1 adrenergic receptor of rat frontal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:The compound was tested for inhibition of [3H]QNB binding to Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of [3H]ketanserin binding to dopamine 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Ability to inhibit the binding of [3H]spiroperidol in rat striatal tissueMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Siena
Curated by ChEMBL
University of Siena
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of human ERG expressed in HEK293 cells coexpressing Kir2.3 after 30 mins by FluxOR based FLIPR assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Siena
Curated by ChEMBL
University of Siena
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells after 30 mins by Rb+ flux assayMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:In vitro inhibitory concentration against radioligand [3H]WB-4101 binding to rat cortical alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Affinity for Dopamine receptors in the rat striatum using [3H]spiroperidol displacement.More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of specific binding of [3H]NANM of sigma binding site in Guinea pig brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of specific binding of [125I]PIPAG to sigma receptor in Guinea pig brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of specific binding of [3H]3-PPP to sigma binding site in Guinea pig brain membranesMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A/1B/1D/1F(Rat)
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor was measured using radioligand ([3H]5-HT) binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor measured using radioligand ([3H]spiperone) binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of 0.1 nM of [125I]- (S)-N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy-benzamide binding in striatal homogenates of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Compound was measured for affinity at 5-hydroxytryptamine 2 receptor in rat cortical by [3H]spiroperidol displacement.More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:The IC50 value was reported as apparent, since [3H]NCA was purported to be irreversible. Result indicates the mean of two separate experiments, each ...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]spiroperidol from dopamine receptor of rat corpus striatum homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]spiroperidol from Dopamine receptor of rat striatum membraneMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:The ability to displace [3H]QNB from Muscarinic acetylcholine receptor in rat brain membrane was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Human)
Chantest
Curated by ChEMBL
Chantest
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of dopamine-sensitive rat brain adenylyl cyclase activity assessed as cAMP levelMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Antagonist activity at recombinant human D3 receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta arrestin2 recruitment p...More data for this Ligand-Target Pair
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as inhibition of quinpirole-induced beta arrestin2 recruitment...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Siena
Curated by ChEMBL
University of Siena
Curated by ChEMBL
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells measured after 30 mins by FluxOR dye based FLIPR TETRA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-P...More data for this Ligand-Target Pair
TargetN-acetyltransferase Eis(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Kentucky
Curated by ChEMBL
University of Kentucky
Curated by ChEMBL
Affinity DataIC50: 390nMAssay Description:Inhibition of Mycobacterium tuberculosis Eis assessed as Eis-mediated kanamycin acetylation preincubated for 10 mins followed by substrate addition a...More data for this Ligand-Target Pair
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.87E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair