BDBM22971 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid::CHEMBL509::Meclofenamate::Meclofenamic acid::US11337935, Compound Meclofenamic-acid::US20240002326, Compound Meclofenamic acid
SMILES Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
InChI Key InChIKey=SBDNJUWAMKYJOX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 47 hits for monomerid = 22971
Affinity DataIC50: 504nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Inhibition of AKR1C3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.74E+3nMAssay Description:Inhibition of AKR1C2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of AKR1C1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of Prostaglandin G/H synthase mediated PGF2-alpha formation in rat basophilic leukemia (RBL-1) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Compound was evaluated for its inhibitory activity against CO(cyclooxygenase)More data for this Ligand-Target Pair
Affinity DataIC50: 2.72E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 740nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Affinity DataIC50: 512nMAssay Description:Inhibition of recombinant human AKR1C3 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetReplicase polyprotein 1a(SARS-CoV)
University of Science and Technology of China
Curated by ChEMBL
University of Science and Technology of China
Curated by ChEMBL
Affinity DataKd: 2.20E+5nMAssay Description:Binding affinity to 15N-labelled His6-tagged SARS-CoV Mac3 (527 to 652 residue) expressed in Escherichia coli Rosetta assessed as chemical shift pert...More data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+5nMAssay Description:Different concentration ranges were tested in the FP-based DNA binding competition assay (0.2-200 uM, 10-500 uM, 10 uM-3 mM), with DMSO concentration...More data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of N-terminal 31 residues truncated His-tagged human FTO demethylase activity expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ALKBH2 demethylase activity by restriction endonuclease digestion assayMore data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase alkB homolog 3(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ALKBH3 demethylase activity by restriction endonuclease digestion assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal His-tagged human ALKBH5 (66 to 292 residues)More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 4 group A member 1(Human)
Goethe University Frankfurt
Curated by ChEMBL
Goethe University Frankfurt
Curated by ChEMBL
Affinity DataEC50: 4.70E+3nMAssay Description:Inhibition of Gal4-fused Nur77 in HEK293T cellsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Goethe University Frankfurt
Curated by ChEMBL
Goethe University Frankfurt
Curated by ChEMBL
Affinity DataEC50: 900nMAssay Description:Inhibition of full-length Nurr1-RXRalpha in human SH-SY5Y cellsMore data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 1.74E+4nMAssay Description:Displacement of dm6A-containing ssDNA from truncated N-terminal his-tagged human FTO (31 residues) mediated demethylation activity expressed in Esche...More data for this Ligand-Target Pair
Affinity DataKd: 480nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+5nMpH: 7.5 T: 2°CAssay Description:The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of the murine wild type Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of the murine Arg120Ala mutant type COX-2More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition 5-lipoxygenase mediated LTB4 formation in rat basophilic leukemia (RBL-1) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of AKR1C4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+4nMAssay Description:Compound was evaluated for its inhibitory activity against 5-LO (5-lipoxygenase)More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+4nMAssay Description:Compound was evaluated in an intact RBL-1 cell line for inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of 5-lipoxygenase measured by the reduction of leukotriene B4 (LTB4) in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged AKR1C4 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...More data for this Ligand-Target Pair
Affinity DataIC50: 8.74E+3nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged AKR1C2 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...More data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged AKR1C1 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...More data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged AKR1C3 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Compound was evaluated in an intact RBL-1 cell line for inhibition of 5-CyclooxygenaseMore data for this Ligand-Target Pair
Affinity DataKi: 256nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by com...More data for this Ligand-Target Pair
Affinity DataKi: 379nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...More data for this Ligand-Target Pair
TargetFatty acid-binding protein, intestinal(Human)
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 8.90E+3nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from I-FABPMore data for this Ligand-Target Pair