BindingDB BDBM22971 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid::CHEMBL509::Meclofenamate::Meclofenamic acid::US11337935, Compound Meclofenamic-acid::US20240002326, Compound Meclofenamic acid

BDBM22971 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid::CHEMBL509::Meclofenamate::Meclofenamic acid::US11337935, Compound Meclofenamic-acid::US20240002326, Compound Meclofenamic acid

SMILES Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl

InChI Key InChIKey=SBDNJUWAMKYJOX-UHFFFAOYSA-N

Data 6 KI 37 IC50 2 Kd 2 EC50

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22971

Transcription factor SOX-18(Human)
University of Queensland

US Patent

BDBM22971(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)

IC50: 1.63E+5nMAssay Description:Different concentration ranges were tested in the FP-based DNA binding competition assay (0.2-200 uM, 10-500 uM, 10 uM-3 mM), with DMSO concentration...More data for this Ligand-Target Pair

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Details US Patent

Filter my 47 hits

Targets 20▿
- Prostaglandin G/H synthase 2 8
- Polyunsaturated fatty acid 5-lipoxygenase 4
- Prostaglandin G/H synthase 1 4
- Alpha-ketoglutarate-dependent dioxygenase FTO 3
- Aldo-keto reductase family 1 member C3 3
- Transthyretin 3
- Aldo-keto reductase family 1 member C1 3
- Prostaglandin G/H synthase 1/2 3
- Aldo-keto reductase family 1 member C4 2
- Aldo-keto reductase family 1 member C2 2
- Transcription factor SOX-18 2
- Fatty acid-binding protein, liver 2
- Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 1
- Platelet-derived growth factor receptor alpha/beta 1
- Fatty acid-binding protein, intestinal 1
- Nuclear receptor subfamily 4 group A member 1 1
- Replicase polyprotein 1a 1
- RNA demethylase ALKBH5 1
- DNA oxidative demethylase ALKBH2 1
- Bile salt export pump 1
Publications 17▿
- Eur J Med Chem 62: 738-44 (2013) 6
- Bioorg Med Chem Lett 12: 521-4 (2002) 4
- J Med Chem 55: 7746-58 (2012) 4
- Proc Natl Acad Sci U S A 96: 7563-8 (1999) 3
- Proc Natl Acad Sci U S A 97: 925-30 (2000) 3
- J Med Chem 51: 3755-64 (2008) 3
- Bioorg Med Chem Lett 2: 705-708 (1992) 2
- J Med Chem 36: 1802-10 (1993) 2
- J Med Chem 58: 6507-15 (2015) 2
- Bioorg Med Chem 26: 5934-5943 (2018) 2
- Bioorg Med Chem Lett 2: 69-72 (1992) 2
- J Med Chem 36: 1090-9 (1993) 1
- US Patent US11337935 (2022) 1
- Drug Metab Dispos 40: 2332-41 (2012) 1
- US Patent US20240002326 (2024) 1
- J Med Chem 65: 15227-15237 (2022) 1
- Cell Chem Biol 24: 346-359 (2017) 1
Institutions 14▿
- University Of Auckland 10
- Vanderbilt University School Of Medicine 4
- TBA 4
- Vanderbilt University School of Medicine 3
- Warner-Lambert 3
- Monash University (Parkville Campus) 3
- St. Bartholomew'S and The Royal London School of Medicine and Dentistry 3
- Guangzhou Medical University 2
- Ume£ 2
- Leland Stanford Junior University 1
- The University of Queensland 1
- University Of Science And Technology Of China 1
- Astrazeneca 1
- University of Queensland 1
Affinity: 40 to 2.2E+5 nM▿
- Ki 6
- IC50 37
- Kd 2
- EC50 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1