BDBM436174 US10590109, Compound 1

SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Oc2ccc3nccnc3c2)c1

InChI Key InChIKey=OLADGUMEIVQDEE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 436174   

TargetFibroblast growth factor receptor 4 [460-802](Human)
Nanjing Innocare Pharma Tech

US Patent
LigandPNGBDBM436174(US10590109, Compound 1)
Affinity DataIC50: 10nMAssay Description:FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Neupharma

US Patent
LigandPNGBDBM436174(US10590109, Compound 1)
Affinity DataIC50: 100nMAssay Description:Inhibitory activities Inhibitory activities of compounds against BRAF, and BRAF V600E were measured by Invitrogen using Z′-LYTE Method as brief...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2020
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Neupharma

US Patent
LigandPNGBDBM436174(US10590109, Compound 1)
Affinity DataIC50: 100nMAssay Description:Inhibitory activities of compounds against KDR (VEGFR2) were also measured by Invitrogen using Z'-LYTE Method as described above with the following m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 1 [308-731](Human)
Nanjing Innocare Pharma Tech

US Patent
LigandPNGBDBM436174(US10590109, Compound 1)
Affinity DataIC50: 1.00E+3nMAssay Description:FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent