BDBM473675 2-(4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4- d]pyrimidin-3-yl)-3-chloro-1H-indole-6- carbonitrile::US10844067, Example 18::US11661423, Example 18
SMILES CC(C)(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)C#N)c2c(N)ncnc12
InChI Key InChIKey=MZFZYAMADRYSBR-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 473675
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology
US Patent
Cancer Research Technology
US Patent
Affinity DataIC50: 6.90nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology
US Patent
Cancer Research Technology
US Patent
Affinity DataIC50: 9.49E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology
US Patent
Cancer Research Technology
US Patent
Affinity DataIC50: 77.5nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology
US Patent
Cancer Research Technology
US Patent
Affinity DataIC50: 6.90nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology
US Patent
Cancer Research Technology
US Patent
Affinity DataIC50: 9.49E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology
US Patent
Cancer Research Technology
US Patent
Affinity DataIC50: 77.5nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair