BDBM50152579 4-(2-Fluoro-phenyl)-2,4-dioxo-butyric acid::CHEMBL364328::Sacchettini_2

SMILES OC(=O)C(=O)CC(=O)c1ccccc1F

InChI Key InChIKey=XWLTWDLBAOMBJP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50152579   

TargetMalate synthase G [C619A](Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
D3R/Abbott

LigandPNGBDBM50152579(4-(2-Fluoro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Affinity DataIC50:  240nMAssay Description:DNTB-Coupled_Enzyme_AssayMore data for this Ligand-Target Pair
In DepthDetails D3R


TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50152579(4-(2-Fluoro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA excision repair protein ERCC-5(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50152579(4-(2-Fluoro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Affinity DataIC50:  7.85E+4nMAssay Description:Concentration required for 50% inhibition of Xeroderma pigmentosum GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetFlap endonuclease 1(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50152579(4-(2-Fluoro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Affinity DataIC50:  1.45E+4nMAssay Description:Concentration required for 50% inhibition of Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed