BDBM50310922 CHEMBL1080241::US9120807, 9::{6-Amino-2-[(pyridin-3-ylmethyl)-amino]-thieno[3,2-d]pyrimidin-4-yl}-thiophen-2-yl-methanone

SMILES Nc1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1

InChI Key InChIKey=TWNISLQLWKPWDI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50310922   

TargetAdenosine receptor A1(Human)
Vernalis (R&D)

US Patent
LigandPNGBDBM50310922(CHEMBL1080241 | US9120807, 9 | {6-Amino-2-[(pyridi...)
Affinity DataIC50:  1.10E+3nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAdenosine receptor A2a(Human)
Vernalis (R&D)

US Patent
LigandPNGBDBM50310922(CHEMBL1080241 | US9120807, 9 | {6-Amino-2-[(pyridi...)
Affinity DataIC50:  1.40E+3nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAdenosine receptor A2a(Human)
Vernalis (R&D)

US Patent
LigandPNGBDBM50310922(CHEMBL1080241 | US9120807, 9 | {6-Amino-2-[(pyridi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A3 [I248L](Human)
Vernalis (R&D)

US Patent
LigandPNGBDBM50310922(CHEMBL1080241 | US9120807, 9 | {6-Amino-2-[(pyridi...)
Affinity DataIC50:  233nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAdenosine receptor A2b(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310922(CHEMBL1080241 | US9120807, 9 | {6-Amino-2-[(pyridi...)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAdenosine receptor A2b(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310922(CHEMBL1080241 | US9120807, 9 | {6-Amino-2-[(pyridi...)
Affinity DataIC50:  7.10nMAssay Description:The use of a Fluorometric Imaging Plate Reader (FLIPR) to measure calcium flux in Adenosine-receptor expressing cells is a well-established technique...More data for this Ligand-Target Pair
In DepthDetails US Patent