BDBM50573595 CHEMBL4855319
SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(NC(=O)CCCCCCC(=O)NO)cc2)ncc1Cl
InChI Key InChIKey=LQLASCOWIMXGMI-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50573595
Affinity DataIC50: 7.90nMAssay Description:Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using Ac-peptide-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chongqing Medical University
Curated by ChEMBL
Chongqing Medical University
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chongqing Medical University
Curated by ChEMBL
Chongqing Medical University
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of ALK (unknown origin) preincubated for 10 mins followed by addition of substrate and ATP for 25 mins by caliper EZ reader methodMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chongqing Medical University
Curated by ChEMBL
Chongqing Medical University
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair