BDBM50573595 CHEMBL4855319

SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(NC(=O)CCCCCCC(=O)NO)cc2)ncc1Cl

InChI Key InChIKey=LQLASCOWIMXGMI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50573595   

TargetHistone deacetylase 1(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573595(CHEMBL4855319)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using Ac-peptide-AMC as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573595(CHEMBL4855319)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573595(CHEMBL4855319)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573595(CHEMBL4855319)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of ALK (unknown origin) preincubated for 10 mins followed by addition of substrate and ATP for 25 mins by caliper EZ reader methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573595(CHEMBL4855319)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Chongqing Medical University

Curated by ChEMBL
LigandPNGBDBM50573595(CHEMBL4855319)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed