BDBM50590390 CHEMBL5174318::US12522603, Compound TDI-007635

SMILES Cn1cc(cn1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO

InChI Key InChIKey=CUFQQVSCNCLUFL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50590390   

TargetCyclic GMP-AMP synthase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590390BDBM50590390(CHEMBL5174318 | US12522603, Compound TDI-007635)
Affinity DataIC50: 14nMAssay Description:Inhibition of human cGASMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMannosyl-oligosaccharide glucosidase(Human)
The Rockefeller University; Memorial Sloan-Kettering Cancer Center

US Patent
LigandChemical structure of BindingDB Monomer ID 50590390BDBM50590390(CHEMBL5174318 | US12522603, Compound TDI-007635)
Affinity DataIC50: 42.8nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Mouse)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590390BDBM50590390(CHEMBL5174318 | US12522603, Compound TDI-007635)
Affinity DataIC50: 442nMAssay Description:Inhibition of mouse cGASMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50590390BDBM50590390(CHEMBL5174318 | US12522603, Compound TDI-007635)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of cGAS in human THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed