BDBM682165 (R)-8-(6-(1-(2-(6- azaspiro[2.5]octan-6- yl)ethoxy)ethyl)pyridin-3-yl)- 3-methyl-1-(tetrahydro-2H- pyran-4-yl)-1H-imidazo[4,5- c]cinnolin-2(3H)-one::US20240207263, Example 107

SMILES C[C@@H](OCCN1CCC2(CC2)CC1)c1ccc(cn1)-c1ccc2nnc3n(C)c(=O)n(C4CCOCC4)c3c2c1

InChI Key InChIKey=WGGFHKWJVGDIHH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 682165   

TargetSerine-protein kinase ATM(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682165(US20240207263, Example 107 | (R)-8-(6-(1-(2-(6- az...)
Affinity DataIC50: 2.80nMAssay Description:ATM (Millipore, Cat. No. 14-933) enzyme solution was prepared in 1x kinase base buffer. 10 ul of 2x enzyme solution was transferred to each well of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682165(US20240207263, Example 107 | (R)-8-(6-(1-(2-(6- az...)
Affinity DataIC50: 1.00E+4nMAssay Description:mTOR Biochemical PotencySolution of mTOR enzymes (Millipore, Cat. No. 14-770) was prepared in 1× kinase buffer at 4-fold of the final concentration (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

LigandPNGBDBM682165(US20240207263, Example 107 | (R)-8-(6-(1-(2-(6- az...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3K Biochemical PotencyPI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682165(US20240207263, Example 107 | (R)-8-(6-(1-(2-(6- az...)
Affinity DataIC50: 1.00E+4nMAssay Description:DNA-PK Biochemical AssayDNA-PK kinase reaction solutions of DNA-PK enzymes (Promega, Cat. No. V4106, Lot. No. 0000224016) were prepared in 1× kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

LigandPNGBDBM682165(US20240207263, Example 107 | (R)-8-(6-(1-(2-(6- az...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3K Biochemical PotencyPI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682165(US20240207263, Example 107 | (R)-8-(6-(1-(2-(6- az...)
Affinity DataIC50: 1.00E+4nMAssay Description:ATR enzyme (batch: Eurofins Cat. No. 14-953) solutions were prepared in 1x kinase base buffer. 10 ul of 2x enzyme solution (final concentration: 2.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

LigandPNGBDBM682165(US20240207263, Example 107 | (R)-8-(6-(1-(2-(6- az...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3K Biochemical PotencyPI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

LigandPNGBDBM682165(US20240207263, Example 107 | (R)-8-(6-(1-(2-(6- az...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3K Biochemical PotencyPI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent