BDBM682227 (S)-1-isopropyl-3-methyl-8-(6-(2,2,2-trifluoro-1-(2-(pyrrolidin-1-yl)ethoxy)ethyl)pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c]cinnolin-2-one and (R)-1-isopropyl-3-methyl-8-(6-(2,2,2-trifluoro-1-(2-(pyrrolidin-1-yl)ethoxy)ethyl)pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c]cinnolin-2-one::US20240207263, Example 184

SMILES CC(C)n1c2c(nnc3ccc(cc23)-c2ccc(nc2)[C@H](OCCN2CCCC2)C(F)(F)F)n(C)c1=O

InChI Key InChIKey=AKYKZTUCGSFAFU-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 682227   

TargetSerine-protein kinase ATM(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682227(US20240207263, Example 184 | (S)-1-isopropyl-3-met...)
Affinity DataIC50: 2.80nMAssay Description:ATM (Millipore, Cat. No. 14-933) enzyme solution was prepared in 1x kinase base buffer. 10 ul of 2x enzyme solution was transferred to each well of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

LigandPNGBDBM682227(US20240207263, Example 184 | (S)-1-isopropyl-3-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3K Biochemical PotencyPI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

LigandPNGBDBM682227(US20240207263, Example 184 | (S)-1-isopropyl-3-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3K Biochemical PotencyPI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682227(US20240207263, Example 184 | (S)-1-isopropyl-3-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:DNA-PK Biochemical AssayDNA-PK kinase reaction solutions of DNA-PK enzymes (Promega, Cat. No. V4106, Lot. No. 0000224016) were prepared in 1× kinase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682227(US20240207263, Example 184 | (S)-1-isopropyl-3-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:mTOR Biochemical PotencySolution of mTOR enzymes (Millipore, Cat. No. 14-770) was prepared in 1× kinase buffer at 4-fold of the final concentration (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682227(US20240207263, Example 184 | (S)-1-isopropyl-3-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:ATR enzyme (batch: Eurofins Cat. No. 14-953) solutions were prepared in 1x kinase base buffer. 10 ul of 2x enzyme solution (final concentration: 2.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

LigandPNGBDBM682227(US20240207263, Example 184 | (S)-1-isopropyl-3-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3K Biochemical PotencyPI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

LigandPNGBDBM682227(US20240207263, Example 184 | (S)-1-isopropyl-3-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3K Biochemical PotencyPI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent