BDBM10755 14C-5-hydroxy tryptamine creatinine disulfate::2-imino-1-methylimidazolidin-4-one; 3-(2-aminoethyl)-1H-indol-5-ol; bis(sulfuric acid)::5-HT::5-Hydroxy Tryptamine::5-hydroxy tryptamine creatinine disulfate::CHEMBL535832::Serotonin::[3H]-5-HT
SMILES NCCc1c[nH]c2ccc(O)cc12
InChI Key InChIKey=QZAYGJVTTNCVMB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 163 hits for monomerid = 10755
Affinity DataKi: 1.05E+3nM ΔG°: -8.15kcal/mole EC50: 12nMpH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
3D Structure (crystal)Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 45nMAssay Description:Partial agonist activity at recombinant human 5-HT1A expressed in CHO-K1 cells by pathhunter beta-arrestin assayMore data for this Ligand-Target Pair
Affinity DataEC50: 70nMAssay Description:Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemil...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 0.166nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 0.170nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Syntex Discovery Research
Curated by PDSP Ki Database
Syntex Discovery Research
Curated by PDSP Ki Database
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Syntex Discovery Research
Curated by PDSP Ki Database
Syntex Discovery Research
Curated by PDSP Ki Database
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
Affinity DataEC50: 2.30nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 0.135nMAssay Description:Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 0.140nMAssay Description:Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 22nMAssay Description:Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 h...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 21nMAssay Description:Agonist activity at human 5-HT2C INI receptor expressed in human HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 20 h...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 33nMAssay Description:Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in ERK1/2 phosphorylation levels i...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 31nMAssay Description:Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumu...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 129nMAssay Description:Biased agonist activity at Gal4-VP16 transcription factor linked human 5-HT1A receptor expressed in human U2OS cells assessed as stimulation of beta-...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 50nMAssay Description:Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured a...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Syntex Discovery Research
Curated by PDSP Ki Database
Syntex Discovery Research
Curated by PDSP Ki Database
Affinity DataEC50: 0.0708nMAssay Description:Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 5.80nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at human 5HT2A receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University Collegium Medicum
Curated by ChEMBL
Jagiellonian University Collegium Medicum
Curated by ChEMBL
Affinity DataEC50: 42nMAssay Description:Agonist activity at human 5HT6 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 33nMAssay Description:Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in ERK1/2 phosphorylation after 15 mins by Alp...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 31nMAssay Description:Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 129nMAssay Description:Biased agonist activity at Gal4-VP16 transcription factor linked human 5-HT1A receptor expressed in human U2OS cells assessed as induction of beta-ar...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 59nMAssay Description:Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobiliz...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 2nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.70nMAssay Description:Agonist activity at human 5-HT7A receptor expressed in HEK cell membranes incubated for 20 mins by cAMP functional assayMore data for this Ligand-Target Pair
Affinity DataEC50: 9.30nMAssay Description:Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader ana...More data for this Ligand-Target Pair
Affinity DataEC50: 9.33nMAssay Description:Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader ana...More data for this Ligand-Target Pair
Affinity DataEC50: 112nMAssay Description:Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion g...More data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion g...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
Sunovion Pharmaceuticals
Curated by ChEMBL
Sunovion Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 3.51E+4nMAssay Description:Agonist activity at recombinant human TAAR1 expressed in CHO-K1 cells assessed as increase in intracellular cAMP incubated for 30 mins by HTRF analys...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 10nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 11nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 398nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assayMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assayMore data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Agonist activity at human 5HT2A receptor transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assayMore data for this Ligand-Target Pair
Affinity DataEC50: 661nMAssay Description:Agonist activity at human 5HT2A S159A mutant transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent a...More data for this Ligand-Target Pair
Affinity DataEC50: 1.67E+3nMAssay Description:Agonist activity at human 5HT2A S159A mutant transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assa...More data for this Ligand-Target Pair
Affinity DataEC50: 0.350nMAssay Description:Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct...More data for this Ligand-Target Pair
Affinity DataEC50: 0.347nMAssay Description:Agonist activity at human 5HT2A receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 0.320nMAssay Description:Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 0.324nMAssay Description:Agonist activity at human 5HT2C receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Syntex Discovery Research
Curated by PDSP Ki Database
Syntex Discovery Research
Curated by PDSP Ki Database
Affinity DataEC50: 0.363nMAssay Description:Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Syntex Discovery Research
Curated by PDSP Ki Database
Syntex Discovery Research
Curated by PDSP Ki Database
Affinity DataEC50: 0.360nMAssay Description:Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct...More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at 5-HT2AR (unknown origin) stably expressed in HEK293 cells measured after 1 hr by fluorescence based Ca2+/Fluo-4 assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Yamanouchi Pharmaceutical
Curated by PDSP Ki Database
Affinity DataEC50: 1.20nMAssay Description:Agonist activity at 5-HT2CR (unknown origin) stably expressed in HEK293 cells measured after 1 hr by fluorescence based Ca2+/Fluo-4 assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Alberta
Curated by PDSP Ki Database
University of Alberta
Curated by PDSP Ki Database
Affinity DataEC50: 10nMAssay Description:Binding affinity of the compound against 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 5.80nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair
Affinity DataEC50: 5.80nMAssay Description:Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye ...More data for this Ligand-Target Pair