BindingDB BDBM10755 14C-5-hydroxy tryptamine creatinine disulfate::2-imino-1-methylimidazolidin-4-one; 3-(2-aminoethyl)-1H-indol-5-ol; bis(sulfuric acid)::5-HT::5-Hydroxy Tryptamine::5-hydroxy tryptamine creatinine disulfate::CHEMBL535832::Serotonin::[3H]-5-HT

BDBM10755 14C-5-hydroxy tryptamine creatinine disulfate::2-imino-1-methylimidazolidin-4-one; 3-(2-aminoethyl)-1H-indol-5-ol; bis(sulfuric acid)::5-HT::5-Hydroxy Tryptamine::5-hydroxy tryptamine creatinine disulfate::CHEMBL535832::Serotonin::[3H]-5-HT

SMILES NCCc1c[nH]c2ccc(O)cc12

InChI Key InChIKey=QZAYGJVTTNCVMB-UHFFFAOYSA-N

Data 399 KI 74 IC50 6 Kd 163 EC50

PDB links: 42 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 10755

5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL

BDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)

Ki: 0.300nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL

BDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)

Ki: 8.20nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL

BDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)

Ki: 8.30nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2C receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL

BDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)

Ki: 13nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL

BDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)

EC50: 55.8nMAssay Description:The receptor (5-hydroxytryptamine 2A ) mediated mobilization of intracellular calcium [Ca2+] was studied in rat smooth muscle cellsMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL

BDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)

IC50: 1.20nMAssay Description:In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair

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3D Structure (crystal)

5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL

BDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)

EC50: 351nMAssay Description:In vitro relative agonist activity against 5-hydroxytryptamine 2A using PI assay in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL

BDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)

IC50: 0.900nMAssay Description:In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL

BDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)

EC50: 3.70nMAssay Description:Tested for functional response on CHO cells expressing cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair

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3D Structure (crystal)

Filter my 641 hits

Targets 49▿
- 5-hydroxytryptamine receptor 1A 108
- 5-hydroxytryptamine receptor 2A 81
- 5-hydroxytryptamine receptor 2C 64
- 5-hydroxytryptamine receptor 7 61
- 5-hydroxytryptamine receptor 4 48
- 5-hydroxytryptamine receptor 1B 46
- 5-hydroxytryptamine receptor 2B 42
- 5-hydroxytryptamine receptor 1D 33
- 5-hydroxytryptamine receptor 6 29
- 5-hydroxytryptamine receptor 5A 16
- 5-hydroxytryptamine receptor 3A 11
- Serotonin 2 (5-HT2) receptor 11
- D(2) dopamine receptor 9
- 5-hydroxytryptamine receptor 1E 8
- 5-hydroxytryptamine receptor 3A/3B 7
- 5-hydroxytryptamine receptor 1F 7
- 5-hydroxytryptamine receptor 5B 6
- Sodium-dependent dopamine transporter 6
- Synaptic vesicular amine transporter 5
- Norepinephrine transporter 3
- D(1A) dopamine receptor 3
- Sodium-dependent serotonin transporter 2
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 2
- 5-hydroxytryptamine 1D receptor 2
- Melatonin receptor type 1A 2
- D(3) dopamine receptor 2
- Alpha-1A adrenergic receptor 2
- 5-hydroxytryptamine receptor 2A/2B/2C 2
- Melatonin receptor type 1B 2
- Isocitrate lyase 2
- Solute carrier family 22 member 1 1
- Solute carrier family 22 member 2 1
- Prostaglandin G/H synthase 2 1
- Solute carrier family 22 member 3 1
- Prostaglandin G/H synthase 1 1
- Insulin-like growth factor 1 receptor 1
- Ribosyldihydronicotinamide dehydrogenase [quinone] 1
- Alpha-glucosidase MAL62 1
- Epidermal growth factor receptor 1
- Macrophage migration inhibitory factor 1
- Alpha-2C adrenergic receptor 1
- MAP/microtubule affinity-regulating kinase 4 1
- Dopamine receptor D4 1
- Polyphenol oxidase 2 1
- D(1B) dopamine receptor 1
- Trace amine-associated receptor 1 1
- Vascular endothelial growth factor receptor 2 1
- Vascular endothelial growth factor receptor 3 1
- Tyrosinase 1
- ...
Publications 50▿
- Neuropharmacology 33: 275-317 (1994) 60
- J Med Chem 59: 9866-9880 (2016) 10
- J Med Chem 46: 4188-95 (2003) 9
- J Med Chem 33: 2087-93 (1990) 8
- J Med Chem 60: 6273-6288 (2017) 8
- J Med Chem 35: 4503-5 (1992) 8
- J Med Chem 46: 2795-812 (2003) 7
- J Med Chem 30: 1-12 (1987) 7
- J Med Chem 37: 2828-30 (1994) 7
- J Med Chem 46: 5117-20 (2003) 7
- J Med Chem 49: 318-28 (2006) 7
- NIDA Res Monogr 178: 440-66 (1998) 6
- Bioorg Med Chem Lett 14: 2367-70 (2004) 6
- Trends Pharmacol Sci 18: 104-7 (1997) 6
- ACS Med Chem Lett 13: 648-657 (2022) 6
- Eur J Med Chem 182: (2019) 6
- J Med Chem 33: 755-8 (1990) 6
- J Med Chem 56: 1211-27 (2013) 6
- J Med Chem 40: 3670-8 (1997) 6
- Bioorg Med Chem Lett 16: 677-80 (2005) 6
- J Med Chem 60: 349-361 (2017) 6
- J Med Chem 61: 9121-9131 (2018) 6
- J Med Chem 32: 543-7 (1989) 6
- Neuropharmacology 36: 621-9 (1997) 5
- Bioorg Med Chem 27: 4163-4173 (2019) 5
- J Med Chem 54: 5320-34 (2011) 4
- J Nat Prod 83: 461-467 (2020) 4
- J Med Chem 38: 2692-704 (1995) 4
- Bioorg Med Chem Lett 8: 1407-12 (1999) 4
- J Pharmacol Exp Ther 276: 720-7 (1996) 4
- Eur J Pharmacol 298: 165-74 (1996) 4
- J Med Chem 62: 2750-2771 (2019) 4
- Bioorg Med Chem 16: 6116-23 (2008) 4
- J Med Chem 63: 10946-10971 (2020) 4
- J Med Chem 65: 12031-12043 (2022) 4
- Bioorg Med Chem Lett 26: 4052-6 (2016) 4
- J Med Chem 36: 1918-9 (1993) 4
- J Med Chem 64: 7453-7467 (2021) 4
- Bioorg Med Chem 18: 3387-402 (2010) 4
- J Med Chem 37: 2509-12 (1994) 4
- Bioorg Med Chem 25: 471-482 (2017) 4
- Bioorg Med Chem 24: 1793-810 (2016) 4
- J Med Chem 31: 867-70 (1988) 4
- Bioorg Med Chem Lett 5: 2391-2396 (1995) 4
- J Med Chem 42: 1556-75 (1999) 4
- J Med Chem 39: 4920-7 (1997) 4
- J Med Chem 64: 13510-13523 (2021) 4
- Br J Pharmacol 115: 622-8 (1995) 4
- J Med Chem 41: 728-41 (1998) 4
- J Med Chem 52: 6946-50 (2009) 3
- ...
Institutions 31▿
- University of Alberta 60
- University Of Illinois At Chicago 24
- Universit£ 22
- Jagiellonian University Medical College 21
- Pfizer 20
- Virginia Commonwealth University 17
- Alcon Research 16
- TBA 11
- Roche Bioscience 11
- University Of Copenhagen 10
- Centre De Recherche Pierre Fabre 8
- Medical College Of Virginia/Virginia Commonwealth University 7
- Glaxosmithkline R&D 7
- Vernalis Research 6
- Northwestern University 6
- University Of Pennsylvania 6
- Sri International 6
- Organix 6
- Vernalis 6
- The University Of Newcastle 6
- Smithkline Beecham Pharmaceuticals 4
- University Of Florida 4
- Usona Institute 4
- Syntex Discovery Research 4
- Cnrs Upr 9023 4
- Eli Lilly 4
- Purdue University 4
- Korea Institute Of Science And Technology 4
- University Of Namur 4
- Universit£T Leipzig 4
- European Research Centre For Drug Discovery And Development (Natsyndrugs) 3
- ...
Affinity: 0 to 6.4E+5 nM▿
- Ki 399
- IC50 74
- Kd 6
- EC50 163
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1