BindingDB BDBM10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS

BDBM10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS

SMILES NS(=O)(=O)Cc1noc2ccccc12

InChI Key InChIKey=UBQNRHZMVUUOMG-UHFFFAOYSA-N

Data 143 KI 2 IC50 3 Kd 1 K_off 1 K_on

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 10888

Carbonic anhydrase 9(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 5.10nM ΔG°: -11.1kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 20nM ΔG°: -10.3kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 2(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 35nM ΔG°: -9.99kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 56nM ΔG°: -9.72kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 6(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 89nM ΔG°: -9.45kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 7(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 117nM ΔG°: -9.29kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 13(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 430nM ΔG°: -8.53kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 14(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 5.25E+3nM ΔG°: -7.08kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 6.03E+3nM ΔG°: -7.00kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 4(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 8.59E+3nM ΔG°: -6.79kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 12(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 1.10E+4nM ΔG°: -6.65kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Carbonic anhydrase 3(Homo sapiens (Human))
Istituto Di Biostrutture E Bioimmagini-Cnr

BDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)

Ki: 2.20E+6nM ΔG°: -3.56kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair

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Filter my 148 hits

Targets 20▿
- Carbonic anhydrase 2 41
- Carbonic anhydrase 1 31
- Carbonic anhydrase 12
- Carbonic anhydrase 6 7
- Carbonic anhydrase 9 7
- Carbonic anhydrase 4 7
- Carbonic anhydrase 14 6
- Carbonic anhydrase 7 6
- Carbonic anhydrase 5A, mitochondrial 6
- Carbonic anhydrase 3 5
- Carbonic anhydrase 5B, mitochondrial 5
- Carbonic anhydrase 12 4
- Amine oxidase [flavin-containing] B 2
- Carbonic anhydrase 13 2
- Beta-carbonic anhydrase 1 2
- Carbonic anhydrase 15 [19-324] 1
- Carbonic anhydrase 15 1
- CARBONIC ANHYDRASE 1
- Amine oxidase [flavin-containing] 1
- Delta carbonic anhydrase 1
- ...
Publications 48▿
- J Med Chem 53: 850-4 (2010) 13
- Chem Biol Drug Des 74: 317-21 (2009) 12
- J Med Chem 54: 1682-92 (2011) 6
- Bioorg Med Chem Lett 18: 6332-5 (2008) 5
- J Med Chem 55: 3891-9 (2012) 5
- Eur J Med Chem 49: 68-73 (2012) 5
- Bioorg Med Chem Lett 18: 4624-7 (2008) 4
- J Enzyme Inhib Med Chem 28: 283-8 (2013) 4
- Bioorg Med Chem 19: 7003-7 (2011) 4
- J Med Chem 54: 3977-81 (2011) 4
- J Enzyme Inhib Med Chem 27: 880-5 (2012) 4
- Bioorg Med Chem Lett 21: 710-4 (2011) 4
- Bioorg Med Chem Lett 22: 1352-7 (2012) 4
- Bioorg Med Chem Lett 21: 1334-7 (2011) 4
- J Med Chem 52: 6421-32 (2009) 4
- Bioorg Med Chem Lett 19: 3170-3 (2009) 3
- Bioorg Med Chem 17: 1158-63 (2009) 3
- J Med Chem 49: 2117-26 (2006) 3
- Bioorg Med Chem Lett 16: 2182-8 (2006) 3
- J Enzyme Inhib Med Chem 28: 316-9 (2013) 3
- Bioorg Med Chem 20: 1403-10 (2012) 3
- J Med Chem 49: 5544-51 (2006) 3
- Bioorg Med Chem Lett 15: 3828-33 (2005) 3
- J Med Chem 54: 909-12 (2012) 3
- Bioorg Med Chem 17: 5054-8 (2009) 3
- Bioorg Med Chem 18: 5498-503 (2010) 2
- Bioorg Med Chem Lett 19: 6649-54 (2009) 2
- Bioorg Med Chem 19: 5023-30 (2011) 2
- Bioorg Med Chem Lett 15: 2315-20 (2005) 2
- J Med Chem 56: 1761-71 (2013) 2
- Bioorg Med Chem 21: 1534-8 (2013) 2
- Chem Biol Drug Des 74: 196-202 (2009) 2
- Bioorg Med Chem 17: 4503-9 (2009) 2
- J Med Chem 52: 646-54 (2009) 2
- Bioorg Med Chem 22: 2939-46 (2014) 2
- Bioorg Med Chem 15: 4152-8 (2007) 2
- Bioorg Med Chem 19: 1847-51 (2011) 2
- Bioorg Med Chem 19: 1172-8 (2011) 2
- Bioorg Med Chem 15: 7229-36 (2007) 1
- J Med Chem 55: 3513-20 (2012) 1
- Bioorg Med Chem Lett 24: 275-9 (2013) 1
- J Med Chem 45: 312-20 (2002) 1
- J Med Chem 52: 2226-32 (2009) 1
- US Patent US10172837 (2019) 1
- J Med Chem 52: 3116-20 (2009) 1
- Bioorg Chem 72: 89-101 (2017) 1
- J Med Chem 51: 2518-21 (2008) 1
- ACS Med Chem Lett 1: 44-8 (2010) 1
Institutions 27▿
- Universit£ 33
- Istituto Di Biostrutture E Bioimmagini-Cnr 17
- Kochi Medical School 16
- Griffith University 14
- Ondokuz Mayis University 9
- Centre Scientifique De Monaco 7
- Ecole Nationale Sup£Rieure De Chimie De Montpellier 5
- Balikesir University 5
- The Hebrew University Of Jerusalem 4
- Agri Ibrahim Cecen University 4
- Artvin£Oruh University 4
- Kirklareli University 3
- Istanbul University 3
- University Of Pavia 3
- Slovak Academy Of Sciences 3
- University Of Tampere And Tampere University Hospital 2
- Universita Degli Studi Di Firenze 2
- University Of Montpellier 2
- University of Tampere 2
- Universite Degli Studi Di Firenze 2
- University Of Naples Federico Ii 2
- Union Life Sciences 1
- Johnson & Johnson Pharmaceutical Research & Development 1
- Naia Metabolic 1
- University Of Namur 1
- University of Karachi 1
- University of Dundee 1
Affinity: 5 to 6.0E+6 nM▿
- Ki 143
- IC50 2
- Kd 3
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1