BDBM13389 4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5-yl)methyl}-2-(naphthalen-1-yl)benzonitrile::A313326::CHEMBL41748
SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12
InChI Key InChIKey=ZBRVJLSHNVWEKS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 13389
TargetProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Globe Pharmaceutical R and Abbott Laboratories
Globe Pharmaceutical R and Abbott Laboratories
Affinity DataIC50: 0.300nMpH: 7.0 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-1 subunit beta(Bos taurus (bovine))
Globe Pharmaceutical R and Abbott Laboratories
Globe Pharmaceutical R and Abbott Laboratories
Affinity DataIC50: 18nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Bovine farnesyl transeferaseMore data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTaseMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 110nMAssay Description:Effective concentration against H-ras processing in transformed NIH3T3 cellsMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTaseMore data for this Ligand-Target Pair
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of Bovine Geranyl geranyl transeferaseMore data for this Ligand-Target Pair