BDBM152151 US8987474, HL1-056 (NSC-117199)

SMILES OS(=O)(=O)c1ccc2NC(=O)\C(=N/Nc3ccccc3[N+]([O-])=O)c2c1

InChI Key InChIKey=UNCWHIJFMMDYME-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 152151   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University of South Florida

US Patent
LigandPNGBDBM152151(US8987474, HL1-056 (NSC-117199) )
Affinity DataIC50:  4.73E+4nMAssay Description:NSC-87877 ranked among top 10% (175th) of the compounds with the best GLIDE scores for the docking to the human Shp2 PTP domain in our virtual screen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University of South Florida

US Patent
LigandPNGBDBM152151(US8987474, HL1-056 (NSC-117199) )
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University of South Florida

US Patent
LigandPNGBDBM152151(US8987474, HL1-056 (NSC-117199) )
Affinity DataIC50:  800nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University of South Florida

US Patent
LigandPNGBDBM152151(US8987474, HL1-056 (NSC-117199) )
Affinity DataIC50:  4.99E+3nMAssay Description:Inhibition of human GST-tagged Shp2 (205 to 593 residues) expressed Escherichia coli DH5alpha assessed as inhibition of PTP activity using DiFMUP as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed