Compile Data Set for Download or QSAR
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Found 4 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 11' and Ligand = 'BDBM152151'
LigandPNGBDBM152151(US8987474, HL1-056 (NSC-117199) )
Affinity DataIC50:  800nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM152151(US8987474, HL1-056 (NSC-117199) )
Affinity DataIC50:  4.99E+3nMAssay Description:Inhibition of human GST-tagged Shp2 (205 to 593 residues) expressed Escherichia coli DH5alpha assessed as inhibition of PTP activity using DiFMUP as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM152151(US8987474, HL1-056 (NSC-117199) )
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM152151(US8987474, HL1-056 (NSC-117199) )
Affinity DataIC50:  4.73E+4nMAssay Description:NSC-87877 ranked among top 10% (175th) of the compounds with the best GLIDE scores for the docking to the human Shp2 PTP domain in our virtual screen...More data for this Ligand-Target Pair
In DepthDetails US Patent